Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis

Fukunaga, Atsushi; Hatakeyama, Mayumi; Tsujimoto, Mariko; Oda, Yoshiko; Washio, Ken; Nishigori, Chikako

doi:10.1111/bjd.13285

Cited by 19 publications

(28 citation statements)

References 10 publications

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“…In this report, QOL information before and after treatment for eight AIGA patients was compared using the Skindex‐16. It was revealed that: (i) QOL impairment for AIGA patients was more severe than that for patients with other dermatological disorders; and (ii) symptom improvement via relevant treatments clearly led to QOL improvement . However, no study has reported on the relationship between severity of AIGA patients and QOL.…”

Section: Discussionmentioning

confidence: 99%

“…It was revealed that: (i) QOL impairment for AIGA patients was more severe than that for patients with other dermatological disorders; and (ii) symptom improvement via relevant treatments clearly led to QOL improvement. 3 However, no study has reported on the relationship between severity of AIGA patients and QOL. Therefore, we focused on AIGA severity and surveyed the correlation between AIGA severity and QOL.…”

Section: Discussionmentioning

confidence: 99%

“…However, only one previous study has reported on QOL for AIGA patients. According to this study, symptom improvement via treatment led to QOL improvement . However, no study has been published thus far regarding the relationship between severity of AIGA patients and QOL.…”

Section: Introductionmentioning

confidence: 86%

“…According to this study, symptom improvement via treatment led to QOL improvement. 3 However, no study has been published thus far regarding the relationship between severity of AIGA patients and QOL. Therefore, we focused on AIGA severity and assessed the correlation between AIGA severity and QOL, as well as severity by Dermatological Life Quality Index (DLQI) subscales.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of the correlation between severity of acquired idiopathic generalized anhidrosis and quality of life scores

Munetsugu

Fujimoto

Satoh

et al. 2017

The Journal of Dermatology

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Symptoms of acquired idiopathic generalized anhidrosis (AIGA) include heat retention and/or heat stroke due to the effects of the disorder on the perspiration ability of the whole body under thermal environmental changes or exercise. Additionally, cholinergic urticaria can also occur in these patients. AIGA has a major impact on everyday life. However, the effects of AIGA severity on the quality of life (QOL) of the patients have not been sufficiently defined. The objective of this study was to evaluate the correlation between AIGA severity and QOL. Study subjects comprised 44 patients diagnosed with AIGA at three registered institutions. AIGA severity assessment was conducted and the Dermatology Life Quality Index (DLQI) questionnaire was administered. Correlations between AIGA severity and DLQI, as well as severity by DLQI subscale, were assessed. We found a positive correlation between total score of AIGA severity criteria and DLQI total scores (R = 0.720, P = 0.001). The impairment increased with the increase in AIGA severity (P < 0.01). In relation to the DLQI subscales, leisure (social and sporting activities) impairment was significantly higher for patients with severe AIGA than those with mild AIGA (P < 0.01). Comparing QOL for AIGA patients with that of patients with other dermatological disorders, it is possible that QOL impairment for AIGA patients is as severe as that for patients with atopic dermatitis. AIGA severity and DLQI are correlated and AIGA patients experience disruption of everyday life more broadly than conventionally perceived.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Evaluation of the correlation between severity of acquired idiopathic generalized anhidrosis and quality of life scores

Munetsugu

Fujimoto

Satoh

et al. 2017

The Journal of Dermatology

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“…The pathomechanism is closely related to the neurotransmission dysfunction on autonomic nerve termini, and the expression of acetylcholine M3 receptor on the secretory portion of eccrine sweat glands is actually decreased in anhidrotic lesion of AIGA patients . The favorable response to systemic corticosteroids including repeated methylprednisolone pulse therapy also supports the immunological hypothesis.…”

Section: Introductionmentioning

confidence: 65%

Serum carcinoembryonic antigen specifically increases among various serum markers of adenocarcinoma in hypohidrosis or conditions related to hypohidrosis

Honma

Nozaki

Nagahata

et al. 2017

The Journal of Dermatology

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Anhidrosis/hypohidrosis are conditions presenting various level of sweating dysfunction. Among them, acquired idiopathic generalized anhidrosis (AIGA) presents inadequate decrease or loss of sweating without apparent neurological and dermatological symptoms except cholinergic urticaria. Recently, serum level of carcinoembryonic antigen (CEA), one of the most well-known tumor markers, has been proposed as a clinical marker reflecting activity of AIGA. This study was performed to verify the specificity and independence of serum CEA level from the other serum tumor markers especially related to adenocarcinoma. The expression of various tumor markers in the serum collected from three healthy control subjects, four AIGA cases, and a cholinergic urticaria (CU) case with elevation of serum CEA level and history of hyperthermia was analyzed using a membrane-based antibody array. In all AIGA and CU cases, the intensity of CEA was significantly increased (7.60-15.9 times compared with that of control), relatively well-reflecting the serum CEA level, and the mean intensity of CEA was 11.8 times higher than the control subjects (P = 0.0011). On the other hand, the ratio of carbohydrate antigen (CA)125 and CA19-9 was 1.93 and 0.23 times compared with the mean intensity of the control subjects, respectively, and there was no statistical significance. Immunohistochemistry on 10 AIGA cases showed increased expression of CEA but not CA19-9 and CA125 in the eccrine sweat glands. In conclusion, the elevation of serum CEA level was independent from the other tumor markers in hypohidrotic condition represented by AIGA.

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A case of atopic dermatitis with hypohidrosis improved after dupilumab treatment

Imamura

Washio

Mizuno

et al. 2020

J Cutaneous Imm & Allergy

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Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis

Cited by 19 publications

References 10 publications

Evaluation of the correlation between severity of acquired idiopathic generalized anhidrosis and quality of life scores

Evaluation of the correlation between severity of acquired idiopathic generalized anhidrosis and quality of life scores

Serum carcinoembryonic antigen specifically increases among various serum markers of adenocarcinoma in hypohidrosis or conditions related to hypohidrosis

A case of atopic dermatitis with hypohidrosis improved after dupilumab treatment

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