Steroid Transport, Local Synthesis, and Signaling within the Brain: Roles in Neurogenesis, Neuroprotection, and Sexual Behaviors

Diotel, Nicolas; Charlier, Thierry; d’Hellencourt, Christian Lefebvre; Couret, David; Trudeau, Vance L.; Nicolau, Joel C.; Meilhac, Olivier; Kah, Olivier; Pellegrini, Elisabeth

doi:10.3389/fnins.2018.00084

Cited by 117 publications

(102 citation statements)

References 398 publications

(527 reference statements)

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“…As cholesterol is an important component of many cellular membranes and is also the substrate for the synthesis of bile acids, steroid hormones and regulating oxysterols, disruption of cholesterol transport may have widespread consequences in cholesterol homeostasis (Diotel et al, 2018;McDonald & Russell, 2010;McMillan & DeMorrow, 2016).…”

Section: Cholesterol Transport In Aldmentioning

confidence: 99%

X‐linked adrenoleukodystrophy: Pathology, pathophysiology, diagnostic testing, newborn screening and therapies

Turk

Theda

Fatemi

et al. 2020

Intl J of Devlp Neuroscience

116

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Adrenoleukodystrophy (ALD) is a rare X‐linked disease caused by a mutation of the peroxisomal ABCD1 gene. This review summarizes our current understanding of the pathogenic cell‐ and tissue‐specific roles of lipid species in the context of experimental therapeutic strategies and provides an overview of critical historical developments, therapeutic trials and the advent of newborn screening in the USA. In ALD, very long‐chain fatty acid (VLCFA) chain length‐dependent dysregulation of endoplasmic reticulum stress and mitochondrial radical generating systems inducing cell death pathways has been shown, providing the rationale for therapeutic moiety‐specific VLCFA reduction and antioxidant strategies. The continuing increase in newborn screening programs and promising results from ongoing and recent therapeutic investigations provide hope for ALD.

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Section: Cholesterol Transport In Aldmentioning

confidence: 99%

X‐linked adrenoleukodystrophy: Pathology, pathophysiology, diagnostic testing, newborn screening and therapies

Turk

Theda

Fatemi

et al. 2020

Intl J of Devlp Neuroscience

116

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“…Sex hormones are critical modulators of adult neuroplasticity and behavior. Sex hormones can either be produced locally in the brain or be synthesized in the gonads and reach the brain through blood circulation (Diotel et al, 2018). Additionally, circulating testosterone can be converted in the brain into its active metabolites through enzymatic action: into DHT (5αdihydrotestosterone) by 5α-reductase, or into estradiol (17β-estradiol) via the enzyme aromatase.…”

Section: Introductionmentioning

confidence: 99%

“…Additionally, circulating testosterone can be converted in the brain into its active metabolites through enzymatic action: into DHT (5αdihydrotestosterone) by 5α-reductase, or into estradiol (17β-estradiol) via the enzyme aromatase. Through their interactions with androgen and estrogen receptors in the brain, sex hormones can mold brain circuits, and thus shape animal behavior in complex ways (Chen et al, 2013;Diotel et al, 2018;Gahr, 2004;Galea, 2008).…”

Section: Introductionmentioning

confidence: 99%

Singing-related reorganization of the song motor circuit is accompanied by a shift in hormonal modulation of song

Rocha

Dreier

Brewer

et al. 2020

Preprint

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Sex hormones are essential modulators of birdsong. Testosterone, and its active androgenic and estrogenic metabolites, 5α-dihydrotestosterone (DHT) and estradiol, can re-shape the brain circuits responsible for song learning and production. The differential mechanisms of action of these different hormones during song development and song maintenance are, nonetheless, not fully understood. Here we demonstrate that unlike testosterone, DHT treatment does not induce singing behavior in naïve adult female canaries that have never previously produced song. However, in birds with previous testosterone-induced singing experience, DHT alone is enough to promote the re-acquisition of high quality songs, even after months of silence. In addition, we show that the synaptic reorganization that accompanies vocal motor skill development requires more than DHT-induced androgen receptor activation. These results indicate that vocal motor practice will persistently modify the hormone-sensitive brain circuit responsible for song production, suggesting a mechanistic differentiation in the hormone-dependent regulation of the initial vocal motor skill acquisition and later re-acquisition.

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“…Numerous reports suggest that estrogens are neuroprotective (Diotel et al. ) and cardioprotective (Knowlton and Lee ; Luo and Kim ) and act as anti‐oxidants that in turn sustain heart health.…”

Section: Introductionmentioning

confidence: 99%

Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice

2018

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We investigated the potential adverse effects of hyperaldosteronism and/or hypoestrogenism on cardiac phenotype, and examined their combined effects in female mice overexpressing cardiac aldosterone synthase (AS). We focused on some signaling cascades challenging defensive responses to adapt and/or to survive in the face of double deleterious stresses, such as Ca2+‐homeostasis, pro/anti‐hypertrophic, endoplasmic reticulum stress (ER stress), pro‐ or anti‐apoptotic effectors, and MAP kinase activation, and redox signaling. These protein expressions were assessed by immunoblotting at 9 weeks after surgery. Female wild type (FWT) and FAS mice were fed with phytoestrogen‐free diet; underwent ovariectomy (Ovx) or sham‐operation (Sham). Ovx increased gain weight and hypertrophy index. Transthoracic echocardiograghy was performed. Both Ovx‐induced heart rate decrease and fractional shortening increase were associated with collagen type III shift. Cardiac estrogen receptor (ER α, ER β) protein expression levels were downregulated in Ovx mice. Hypoestrogenism increased plasma aldosterone and MR protein expression in FAS mice. Both aldosterone and Ovx played as mirror effects on up and downstream signaling effectors of calcium/redox homeostasis, apoptosis, such as concomitant CaMKII activation and calcineurin down–regulation, MAP kinase inhibition (ERK1/2, p38 MAPK) and Akt activation. The ratio Bcl2/Bax is in favor to promote cell survivor. Finally, myocardium had dynamically orchestrated multiple signaling cascades to restore tolerance to hostile environment thereby contributing to a better maintenance of Ca2+/redox homeostasis. Ovx‐induced collagen type III isoform shift and its upregulation may be important for the biomechanical transduction of the heart and the recovery of cardiac function in FAS mice. OVX antagonized aldosterone signaling pathways.

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Steroid Transport, Local Synthesis, and Signaling within the Brain: Roles in Neurogenesis, Neuroprotection, and Sexual Behaviors

Cited by 117 publications

References 398 publications

X‐linked adrenoleukodystrophy: Pathology, pathophysiology, diagnostic testing, newborn screening and therapies

X‐linked adrenoleukodystrophy: Pathology, pathophysiology, diagnostic testing, newborn screening and therapies

Singing-related reorganization of the song motor circuit is accompanied by a shift in hormonal modulation of song

Effects of hypoestrogenism and/or hyperaldosteronism on myocardial remodeling in female mice

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