Steroid Therapy and Strongyloidiasis

Willis, Amanda; Nwokolo, Chuka U.

doi:10.1016/s0140-6736(66)90303-5

Cited by 46 publications

(18 citation statements)

References 10 publications

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“…[14][15][16][17][18] Risk factors for dissemination are shown in Box 1. Details of these mechanisms remain unclear, as there are have been cases of hyperinfection in people with no identifiable immunodeficiency.…”

Section: Risk Factors For Disseminationmentioning

confidence: 99%

Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management

Lim¹

2004

Canadian Medical Association Journal

158

173

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STRONGYLOIDIASIS, WHICH IS CAUSED by the nematode Strongyloides stercoralis, is a common and persistent infection, particularly in developing countries. In the setting of compromised cellular immunity, it can result in fulminant dissemination with case-fatality rates of over 70%. The majority of new Canadian immigrants come from countries where Strongyloides is highly endemic; therefore, the burden of Strongyloides may be underappreciated in Canada. Because early diagnosis and therapy can have a marked impact on disease outcome, screening for this infection should be considered mandatory for patients who have a history of travel or residence in a disease-endemic area and risk factors for disseminated disease (e.g., corticosteroid use and human Tlymphotropic virus type I infection).

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Section: Risk Factors For Disseminationmentioning

confidence: 99%

Complicated and fatal Strongyloides infection in Canadians: risk factors, diagnosis and management

Lim¹

2004

Canadian Medical Association Journal

158

173

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“…7 The present patient was also not in an immunosuppressed condition, except that he had taken corticosteroid intermittently for his gouty arthritis for approximately 20 years, with average doses of 30 mg prednisolone every 2 months. The intermittent steroid treatment may be associated with the development of pericardial Strongyloidiasis, 8 although he was not ever on long-term steroid therapy.…”

Section: Discussionmentioning

confidence: 99%

Strongyloides Stercoralis Infection With Bloody Pericardial Effusion in a Non-Immunosuppressed Patient.

Lai

Hsu

Wang

et al. 2002

Circ J

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“…Some authors believe that the urticaria ofstronglyloidiasis may be due to an allergic reaction to the protease secreted by the larva rather than to the larva per se. Our case suggests that even low doses of steroids may alter the host parasite equilibrium lead ing to a suppression of the inflammatory and immunologic response [9,10]. …”

mentioning

confidence: 81%