Steroid sulfatase gene variation and DHEA responsiveness to resistance exercise in MERET

Abstract

Genetic influences and endurance exercise have been shown to alter circulating concentrations of dehydroepiandrosterone (DHEA) and its sulfated conjugate, DHEAS. We hypothesized that acute resistance exercise (RE) and training (RET) would increase DHEA steroids, and the magnitude of the increase would be influenced by a steroid sulfatase (STS) gene variation. Fasting blood samples were collected before and after the first (S1) and last (S30) session of a 10-wk RET program in 62 men and 58 women [age: 21.0 yr (2.4)]. Acute RE increased both DHEA [+2.8 (0.4), S1; +1.6 ng/ml (0.4), S30; P < 0.001] and DHEAS [+154 (24), S1; +166 ng/ml (15), S30; P < 0.001] and decreased DHEAS:DHEA [-27 (8), S1; -15 (7), S30; P < 0.01]. RET reduced resting DHEAS (-122 ng/ml, P < 0.01) and decreased DHEA response to RE (-50%, P < 0.05). Subjects with an STS "G" allele (n = 36) had greater acute changes in DHEA [+4.4 (0.7) vs. +2.0 ng/ml (0.5), S1; +3.2 (0.6) vs. +1.0 ng/ml (0.4), S30; P < 0.01] and DHEAS:DHEA [-37 (11) vs. 5 (7), S30, P < 0.05] than those subjects with only an "A" allele (n = 84). The observed increase in DHEA and DHEAS and decrease in DHEAS:DHEA suggest RE-induced STS activation which is influenced by the STS polymorphism.

Hormonal Responses to Resistance Exercise during Different Menstrual Cycle States

“…Riechman et al (29) reported that acute resistance exercise increased blood DHEAS levels. The exercise-induced increases in DHEAS concentrations have been attributed to an increased rate of secretion from the adrenal cortex in response to ACTH stimulation (16).…”

“…In addition, the resting serum level of testosterone in women is about 10 times lower than that in tnen. Riechman et al (29) showed that acute resistance exercise induces increased DHEAS, a peripheral precursor of testosterone, in both men and women. These results indicated that there are sex differences in basal anabolic homione levels and responses to exercise.…”

1α,25‐dihydroxyvitamin D3‐mediated stimulation of steroid sulphatase activity in myeloid leukaemic cell lines requires VDRnuc‐mediated activation of the RAS/RAF/ERK‐MAP kinase signalling pathway

“…STS expression increases in human fallopian epithelial cells during the early luteal phase and recedes during the follicular phase of the menstrual cycle [Yanaihara et al, 2001]. STS activity/expression is also transiently increased during acute or chronic exercise [Riechman et al, 2004] and in the adrenals of stressed animals [Dominguez et al, 1975]. STS activity becomes deregulated as part of several hormone-mediated disorders.…”

The Role of Dehydroepiandrosterone Levels on Physiologic Acclimatization to Chronic Mountaineering Activity

“…The underlying nature for this discrepancy is unknown. Variation in the DHEA-S level, which can be influenced by environmental and genetic factors (Riechman et al, 2004;Smit et al, 2005), could be one possibility that explains the different results for this aspect in response to altitude challenge.…”