Steroid Studies on Urine From Mothers of Mongoloid Infants

Thyroid Autoantibodies and Satellite Associations in Down’s Syndrome

“…There are d ata to show th a t TAA occur more frequently in gonadal dysgenesis [12,14,32,34], in DS children [5 ,1 2 ,1 6 ,2 1 ,2 7 , 31] and in th e parents of DS children [10,12] th an in norm al persons. Such findings are supported by publications •< -reporting on a com bination of gonadal dysgenesis and thyroid dysfunction [14,32], and by the observation th a t thyroid diseases occur more frequently in the m others of children suffering from DS [7,8]. On the other hand, Wren and his associates [35] found no cor relation between the presence of TAA and DS.…”

On the possible effects of homeostatic shifts in human embryonic development

“…There have been some documented cases reported in the literature with emphasis on the Down's syndrome, rather than the less frequent trisomies (i.e., 13 and 18). In fact, high levels of BRM, such as those observed in hyperthyroidism during the first term in pregnancy (Hawe & Francis, 1962), indicate a risk factor for trisomies (Ek, 1959;Coppen & Cowie, 1950;Van Wijck et al, 1961;Fialkow et M., 1965;Nilsson, Hansson & Nilsson, 1975). The observation that some of the reports have not been confirmed later (such as the work of Ek on 41 mothers of Down's syndrome children), may be due to longer time intervals allowed between the birth of the affected children and the examination of the mother as has been pointed out by some authors (Nflsson, Hansson & Nilsson, 1975;Vogel & Motulsky, 1986a).…”