Steroid-specific regulation of agonistic responding in the anterior hypothalamus of male hamsters

Hayden-Hixson, Diane M.; Ferris, Craig F.

doi:10.1016/0031-9384(91)90020-o

Cited by 93 publications

(40 citation statements)

References 37 publications

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“…For instance, whereas high basal CRT levels are related to inhibition of aggression, acute administration of glucocorticoids stimulates aggression (in rodents) (Hayden-Hixson and Ferris 1991). This paradox could be explained by the negative feedback-loop mechanism that is initiated in case of elevated glucocorticoid levels.…”

Section: Effects Of Basal and Exogenous Cortisol And Testosterone On mentioning

confidence: 99%

Testosterone, cortisol, and serotonin as key regulators of social aggression: A review and theoretical perspective

et al. 2011

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In human and non-human animals the steroid hormones cortisol and testosterone are involved in social aggression and recent studies suggest that these steroids might jointly regulate this behavior. It has been hypothesized that the imbalance between cortisol and testosterone levels is predictive for aggressive psychopathology, with high testosterone to cortisol ratio predisposing to a socially aggressive behavioral style. In this review, we focus on the effects of cortisol and testosterone on human social aggression, as well as on how they might modulate the aggression circuitry of the human brain. Recently, serotonin is hypothesized to differentiate between impulsive and instrumental aggression, and we will briefly review evidence on this hypothesis. The aim of this article is to provide a theoretical framework for the role of steroids and serotonin in impulsive social aggression in humans.

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Section: Effects Of Basal and Exogenous Cortisol And Testosterone On mentioning

confidence: 99%

Testosterone, cortisol, and serotonin as key regulators of social aggression: A review and theoretical perspective

et al. 2011

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“…Interestingly, 17α-estradiol or testosterone do not produce similar effects. HaydenHixson and colleagues also showed that a microinjection of E 2 in the anterior hypothalamus stimulates agonistic behavior (flank marking) within 15 min in male hamsters [110].…”

Section: Introductionmentioning

confidence: 96%

“…This rapidity of action is all the more striking that most of these effects were observed following systemic injections [33,64,69,208] so that the hormone had first to reach the target tissue and accumulate above a certain threshold before it could activate a cellular response and trigger the neuronal circuits involved in the expression of the behavior considered. Alternatively, most of the intra-tissue applications were performed via insertion of hormone in crystals [110,126,138]. It is thus likely that some time was required to dissolve hormone from these implants and produce a behaviorally active concentration of E 2 .…”

Section: Introductionmentioning

confidence: 99%

“…But there are some examples of an estrogen implant applied only for a brief period in a specific brain area that activates the expression of complex behaviors in the absence of steroid priming i.e. in the absence of activation of specific circuits involved in the control of these behaviors [110,126,138,264,265]. Finally, fast effects of estrogen, and other steroids, have been identified in various vertebrate species (for review, see [206]).…”

Section: Introductionmentioning

confidence: 99%

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Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from?

2006

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Estrogens exert a wide variety of actions on reproductive and non-reproductive functions. These effects are mediated by slow and long lasting genomic as well as rapid and transient non-genomic mechanisms. Besides the host of studies demonstrating the role of genomic actions at the physiological and behavioral level, mounting evidence highlights the functional significance of non-genomic effects. However, the source of the rapid changes in estrogen availability that are necessary to sustain their fast actions is rarely questioned. For example, the rise of plasma estrogens at pro-estrus that represents one of the fastest documented changes in plasma estrogen concentration appears too slow to explain these actions. Alternatively, estrogen can be synthesized in the brain by the enzyme aromatase providing a source of locally high concentrations of the steroid. Furthermore, recent studies demonstrate that brain aromatase can be rapidly modulated by afferent inputs, including glutamatergic afferents. A role for rapid changes in estrogen production in the central nervous system is supported by experiments showing that acute aromatase inhibition affects nociception as well as male sexual behavior and that preoptic aromatase activity is rapidly (within min) modulated following mating. Such mechanisms thus fulfill the gap existing between the fast actions of estrogen and their mode of production and open new avenues for the understanding of estrogenic effects on the brain.

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“…In 1991, Hayden-Hixon and Ferris (29) reported that estrogen injections into the anterior hypothalamus of male hamsters caused rapid behavioral changes, i.e., increased fl ank marking. Similar rapid behavioral changes were also found in experiments involving rats, in which estrogen administration facilitated anogenital investigation and mounting behavior within 35 min (30) .…”

Section: Non-genomic Actions Of Estrogen Involved In Physiological Prmentioning

confidence: 99%

Genomic and non-genomic actions of estrogen: recent developments

Azuma

Inoue²

2012

BioMolecular Concepts

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Estrogen affects transcriptional status by activating its corresponding nuclear receptor, the estrogen receptor (ER). It can also induce rapid cellular reactions within a few minutes, and this feature cannot be explained by the transcription-mediated effects of estrogen. The latter mechanisms are called 'non-genomic actions' of estrogen. In contrast, the former classic modes of action came to be called 'genomic actions'. One of the recent developments of research on estrogen was the substantiation of the non-genomic actions of estrogen; these were initially observed and reported as intriguing phenomena more than 40 years ago. The interacting molecules as well as the biological significance of non-genomic actions have now been shown. In the field of genomic actions, invention and spread of new technologies, including high-throughput sequencers, promoted a comprehensive view of estrogen-mediated transcriptional regulation.

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Steroid-specific regulation of agonistic responding in the anterior hypothalamus of male hamsters

Cited by 93 publications

References 37 publications

Testosterone, cortisol, and serotonin as key regulators of social aggression: A review and theoretical perspective

Testosterone, cortisol, and serotonin as key regulators of social aggression: A review and theoretical perspective

Functional significance of the rapid regulation of brain estrogen action: Where do the estrogens come from?

Genomic and non-genomic actions of estrogen: recent developments

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