Steroid-Sensitive Minimal Change Nephrotic Syndrome

Lewis, Malcolm; Baildom, E. M.; Davies, N.; Houston, I. B.; Postlethwaite, R J

doi:10.1159/000415405

Cited by 7 publications

(3 citation statements)

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“…Evidence and rationale While children are less likely to relapse as they grow older [281], more than 10% (6.8-42.2%) of childhood-onset SSNS patients still experience relapses during adulthood [6,7,[282][283][284][285][286]. Risk factors of continued active disease during adulthood are earlier onset of NS [129,282,285], early relapse after onset [6,287], FRNS or SDNS [6,7,[284][285][286][287], and duration of remission < 6 years [283,288].…”

Section: Rate Of Transition Support Of Transitionmentioning

confidence: 99%

Section: Rate Of Transition Support Of Transitionmentioning

confidence: 99%

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IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome

Trautmann

Boyer²,

Hodson³

et al. 2022

Pediatr Nephrol

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Idiopathic nephrotic syndrome is the most frequent pediatric glomerular disease, affecting from 1.15 to 16.9 per 100,000 children per year globally. It is characterized by massive proteinuria, hypoalbuminemia, and/or concomitant edema. Approximately 85–90% of patients attain complete remission of proteinuria within 4–6 weeks of treatment with glucocorticoids, and therefore, have steroid-sensitive nephrotic syndrome (SSNS). Among those patients who are steroid sensitive, 70–80% will have at least one relapse during follow-up, and up to 50% of these patients will experience frequent relapses or become dependent on glucocorticoids to maintain remission. The dose and duration of steroid treatment to prolong time between relapses remains a subject of much debate, and patients continue to experience a high prevalence of steroid-related morbidity. Various steroid-sparing immunosuppressive drugs have been used in clinical practice; however, there is marked practice variation in the selection of these drugs and timing of their introduction during the course of the disease. Therefore, international evidence-based clinical practice recommendations (CPRs) are needed to guide clinical practice and reduce practice variation. The International Pediatric Nephrology Association (IPNA) convened a team of experts including pediatric nephrologists, an adult nephrologist, and a patient representative to develop comprehensive CPRs on the diagnosis and management of SSNS in children. After performing a systematic literature review on 12 clinically relevant PICO (Patient or Population covered, Intervention, Comparator, Outcome) questions, recommendations were formulated and formally graded at several virtual consensus meetings. New definitions for treatment outcomes to help guide change of therapy and recommendations for important research questions are given.

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Section: Rate Of Transition Support Of Transitionmentioning

confidence: 99%

Section: Rate Of Transition Support Of Transitionmentioning

confidence: 99%

IPNA clinical practice recommendations for the diagnosis and management of children with steroid-sensitive nephrotic syndrome

Trautmann

Boyer²,

Hodson³

et al. 2022

Pediatr Nephrol

View full text Add to dashboard Cite

show abstract

“…17.2). [10][11][12] Boys are twice as likely to be affected as are girls, but the sex incidence is equal in adolescents and adults. There are data suggesting that MCD has become less common in adults.…”

Section: Epidemiologymentioning

confidence: 99%