Steroid-Responsive Retinal Vasculitis With a Frosted Branch Appearance in Crohns Disease

Sykes, Scott O.; Horton, Jonathan C.

doi:10.1097/00006982-199709000-00017

Cited by 19 publications

(9 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The etiology of this disorder is clear only in secondary cases where an autoimmune disease such as Lupus (7), Crohn's disease (8), leukemia (9), lymphoma (2) or viral infection (10) are present. In these cases, frosted branch angiitis is a clinical sign mediated by immune complex deposition in the vessel walls, direct infection or infiltration by malignant cells (2).…”

Section: Discussionmentioning

confidence: 99%

A New Case of Acute Idiopathic Frosted Branch Angiitis in Europe

Huerva¹,

Puig

Sánchez³

et al. 2002

European Journal of Ophthalmology

View full text Add to dashboard Cite

Case Report A 20-year-old male with no history of any systemic or eye disease developed loss of visual acuity in both eyes. White exudates surrounding the retinal veins from the posterior pole to the periphery, retinal edema and hemorrhages in both eyes were evident on ophthalmoscopy. Fluorescein angiography showed leakage of the dye from the veins and extensive staining of the vein walls. A diagnosis of acute frosted branch angiitis was made. Systemic examination revealed axillary, submandibular and inguinal lymphadenopathies. VCA IgM antibody for Epstein-Barr virus was negative and IgG positive. Biopsy was taken of an axillary lymph node; a non-specific inflammatory reaction was found on anatomopathologic study. The patient was started on 90 mg prednisolone daily. After two weeks retinal vasculitis had improved and the lymphadenopathies soon resolved. Small, hard exudates were present in the posterior pole during absorption of the retinal edema and resolution of the vascular inflammation. Systemic prednisolone were reduced progressively and definitively withdrawn two months later. The patient's visual acuity was 20/25 in both eyes. No fibrotic scar tissue or atrophic lesions were noted in either fundus. Conclusions We report a new case of acute frosted branch angiitis with an onset and favorable clinical course similar to previous reports. We found the additional presence of lymphadenopathies but have been unable to establish a possible causal agent. To our knowledge, apart from a recent case of frosted branch angiitis-like response in Greece, the present case is the first reported in western Europe.

show abstract

Section: Discussionmentioning

confidence: 99%

A New Case of Acute Idiopathic Frosted Branch Angiitis in Europe

Huerva¹,

Puig

Sánchez³

et al. 2002

European Journal of Ophthalmology

View full text Add to dashboard Cite

show abstract

“…Ito et al [ 1 ] first coined the term frosted branch angiitis in 1976 where they reported the appearance of thick perivascular sheathing in a 6-year-old boy’s fundus recalling imagery of frosted tree branches during an icy winter. Frosted branch angiitis may be idiopathic or associated with various systemic conditions including SLE [ 2 , 3 ], Behcet’s disease [ 4 ], Crohn’s disease [ 5 ], cytomegalovirus (CMV) retinitis [ 6 ], herpes simplex type 2 infection [ 7 ], mycobacterium tuberculosis infection [ 8 ], T. gondii infection [ 9 ], various other viral and bacterial infections [ 10 ], aseptic meningitis [ 11 ], and blood dyscrasias such as leukemia [ 12 ] and lymphoma [ 13 ]. Additional retinal findings may include intraretinal hemorrhages, hard exudates, and serous exudative detachments of the macula and periphery.…”

Section: Resultsmentioning

confidence: 99%

Bilateral frosted branch angiitis as the presenting sign of antiphospholipid antibody syndrome

Wood

Wong

2016

J Ophthal Inflamm Infect

View full text Add to dashboard Cite

Background“Frosted branch retinal angiitis” is an encompassing term for a rare, typically bilateral diffuse retinal periphlebitis that may occur in a number of varying conditions. To our knowledge, we report the first case of frosted branch angiitis as the presenting sign of antiphospholipid antibody syndrome in a 28-year-old woman.FindingsThis study is a retrospective case report and literature review. Serial fundus photos, fluorescein angiogram, and ocular coherence tomography taken were before and after treatment, showing resolution of diffuse retinal perivascular sheathing and macular edema along with marked improvement in visual acuity 4 months after the treatment with corticosteroids.ConclusionsFrosted branch angiitis can be seen in association with antiphospholipid antibody syndrome. Prompt recognition and treatment with corticosteroids may result in good visual prognosis, and long-term immunosuppression and additional anticoagulation may be beneficial to prevent recurrence.

show abstract

“…Kleiner64 classified the patients with the appearance of frosted branch angiitis into three subgroups-First are patients with lymphoma or leukemia64 whose disease is due to infiltration with malignant cells (frosted branch-like appearance) [Figure 15] Second is the group of patients who have associated viral infections or autoimmune disease. Frosted branch angiitis was reported in patients with systemic lupus erythematosus,26 Crohn's disease,65 toxoplasmic retinochoroiditis,3536 human T cell lymphoma virus type 1 infection,50 AIDS associated with small patches of retinitis,4243 HIV without CMV retinitis,46 herpes simplex virus infection,66 and Epstein-Barr virus infection 67. In these patients, frosted branch angiitis is a clinical sign, possibly of immune complex deposition (secondary frosted branch angiitis).…”

Section: Fundus Fluorescein Angiographymentioning

confidence: 98%