Steroid response in moderate to severe pediatric ulcerative colitis: a single center’s experience

Abstract

approximately half of the pediatric patients had complete response to steroid therapy in a long period. PUCAS could be used as a potential marker of "failed response" to steroid, but should be supported with a number of prospective randomized controlled studies.

Management of Paediatric Ulcerative Colitis, Part 1

“…Studies of oral steroids for treating children with active UC report short term (1-3 months) remission rates of 50-64% (108)(109)(110); at one year 49-61% had prolonged response, 14-49% were steroid-dependent and 5-29% required surgery (5,7,108,110). Mucosal healing lags behind clinical improvement; in a non-randomised study after 8 weeks of steroids or 5-ASA, 87% had clinical remission, 40% endoscopic remission and 15% histological remission with no significant difference in outcomes between the two therapies (111).…”

Inflammatory bowel disease in Turkish children

“…PUCAI was developed for the noninvasive assessment of disease activity in patients with UC, and it was shown that it may be used for the prediction of steroid response. [30,31] Recently, a strong correlation was found between PUCAI and the likelihood of undergoing surgical procedure. [32] CRP and erythrocyte sedimentation rate were used in the diagnosis of UC, but the results were different.…”

Medical management of pediatric inflammatory bowel disease in the Asia‐Pacific region: A position paper by the Asian Pan‐Pacific Society for Pediatric Gastroenterology, Hepatology, and Nutrition (APPSPGHAN) PIBD Working Group

“…In UC, systemic CS is an effective treatment of moderate‐to‐severe disease, including acute severe colitis (ASC). Reported short term remission rates (1–3 months) ranged from 50 to 64% 48–50 and 1‐year remission rates ranging from 49% to 61% 48–50 . However, a substantial proportion (14–49%) of children became steroid‐dependent by 1 year 48,49 …”

“…Reported short term remission rates (1–3 months) ranged from 50 to 64% 48–50 and 1‐year remission rates ranging from 49% to 61% 48–50 . However, a substantial proportion (14–49%) of children became steroid‐dependent by 1 year 48,49 …”