Steroid Release from Silicone Elastomer Containing Excess Drug in Suspension

Nicotine Base Permeation through Silicone Elastomers: Comparison of Dimethylpolysiloxane and Trifluoropropylmethylpolysiloxane Systems

“…Solubility of the permeant in the membrane also plays a significant part in the overall permeation process (13, 22). For polar or unsaturated molecules, an accurate value for this parameter is not easily determined, since commercial silicone rubbers generally contain porous fillers that may adsorb or sequester permeant molecules (23).…”

Membrane Diffusion I: Design and Testing of a New Multifeatured Diffusion Cell

“…These must be accomplished without sacrifice of analytical sensitivity. Many cell prototypes can be found in the literature (1)(2)(3)(4)(5)(6)(7)(8)(9)(10)(11)(12) and, considering that most were constructed for similar purposes, their diversity is remarkable. However, a rough classification based on gross similarity or dissimilarity of the donor and receptor compartment size and geometry is possible.…”

“…Typical examples were described by Poulsen (4), Tregear (9, and Haleblian et aZ. (6). The major problem with these systems is adequate and uniform control of stirring.…”

Hormonal Therapy with Steroid-Filled Silastic Rubber Implants

“…Above all, this therapy is almost independent of cooperation by the patient. The pharmacokinetical principles of this way of hormone administration have been well established in numerous in vitro [15,16,18,25] and in vivo [5-7, 14, 19, 22, 27] investigations, primarily by authors interested in long term contraception in the female [26], The releasing factor, i.e. the amount of steroid released from the capsule within a certain time, is proportionate to the surface area of the PDS capsule and indirect proportionate to its thickness.…”

“…Steroids diffuse readily through polydimethylsiloxane (PDS) membranes (silastic, Dow Corning Corp.) into various media at a relatively constant, low rate [13,15,18,25]. Subcutaneous implantation of PDS capsules filled with dry, cristalline hormone assures a good constancy of hormonal supply í 1 2.41mm 1.58 mm i 1 to the organism over longer periods of time [5][6][7][8][9]22], As this results in an optimal steadiness of hormone concentration at the site of action, the steroid is utilized more efficiently and its biological effectiveness increased [6].…”