“…Above all, this therapy is almost independent of cooperation by the patient. The pharmacokinetical principles of this way of hormone administration have been well established in numerous in vitro [15,16,18,25] and in vivo [5-7, 14, 19, 22, 27] investigations, primarily by authors interested in long term contraception in the female [26], The releasing factor, i.e. the amount of steroid released from the capsule within a certain time, is proportionate to the surface area of the PDS capsule and indirect proportionate to its thickness.…”