Steroid receptors and their ligands: Effects on male gamete functions

Aquila, Saveria; Amicis, Francesca De

doi:10.1016/j.yexcr.2014.07.015

Cited by 48 publications

(28 citation statements)

References 130 publications

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“…One of the most pronounced effects is on body temperature and the thermoregulatory system (Gagnon & Kenny, ). Alpha‐ and beta‐oestrogen receptors are found throughout the body including the central nervous system (Kim & Bender, ; Aquila & De Amicis, ; Paterni et al ., ). These receptors control a variety of functions including tissue synthesis of protein, tissue blood flow and body temperature (Canonico, ; Inoue et al ., ; Petrofsky et al ., , ; Stephenson & Kolka, ).…”

Section: Discussionmentioning

confidence: 99%

Sudomotor and vasomotor activity during the menstrual cycle with global heating

Petrofsky

Lee

Khowailed

2015

Clin Physio Funct Imaging

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Many studies have reported that there are changes in sympathetic activity throughout the menstrual cycle as there are oestrogen receptor in the hypothalamus and all other parts of the sympathetic nervous system. The purpose of this study was to see whether there were variations in sympathetic activity, skin vasomotor and sweat gland sudomotor rhythms during the menstrual cycle. Eight young female subjects with a regular menstrual cycle participated in the study. Subjects were tested once during the follicular phase and once during the luteal phase. Skin blood flow and sweat rate were significantly higher in the luteal phase compared with the follicular phase (p < .05), but the frequency and magnitude of sudomotor and vasomotor rhythms were significantly greater in the follicular phase (p < .05). In contrast, spectral data showed less sympathetic activity in the luteal phase. A significant finding here is that the sudomotor rhythm of sweat glands is altered by the menstrual cycle.

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Section: Discussionmentioning

confidence: 99%

Sudomotor and vasomotor activity during the menstrual cycle with global heating

Petrofsky

Lee

Khowailed

2015

Clin Physio Funct Imaging

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“…Estrogen administration decreases LDL cholesterol and Lp(a) levels while increasing triglycerides and HDL cholesterol levels, but these effects are dependent on the dose and route of administration [143]Estrogens improve inflammation related to metabolic dysfunction (“metaflammation”). Further to a direct downregulation of inflammatory pathways, this effect is also mediated by metabolic amelioration [144]Obesity is associated with hyperestrogenism which, in turn, increases the risk of breast cancer in men [145]ProgesteroneProgesterone has important effects in regulating male fertility by affecting the energetic homeostasis of sperm [146]Progesterone has a major role in the ovarian and menstrual cycle; moreover it exerts an immuno regulatory function; regulates the contraction of human intestinal smooth muscle cells and the motility of various human cell types [147]Progesterone is an independent predictor of insulin resistance in girls [148]Progesterone has been potentially implicated as a therapeutic adjunct in many clinical conditions such as traumatic brain injury, Alzheimer’s disease, and diabetic neuropathy [147]Increasing levels of progesterone have been associated with the development of systemic insulin resistance [149]Little is known regarding the role, if any, of serum progesterone in NAFLDAndrogensThe synthesis of testosterone is key to male fertility. A negative feedback finely regulates the secretion of hormones at the levels of hypothalamic-pituitary–gonadal axis.…”

Section: Role Of Gender Reproductive Status and Age In The Heterogementioning

confidence: 99%

NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk

et al. 2017

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Nonalcoholic fatty liver disease (NAFLD) spans steatosis through nonalcoholic steatohepatis, cirrhosis, and hepatocellular carcinoma (HCC) associated with striking systemic features and excess cardiovascular and liver-related mortality. The pathogenesis of NAFLD is complex and multifactorial. Endocrine derangements are closely linked with dysmetabolic traits. For example, in animal and human studies, female sex is protected from dysmetabolism thanks to young individuals’ ability to partition fatty acids towards ketone body production rather than very low density lipoprotein (VLDL)-triacylglycerol, and to sex-specific browning of white adipose tissue. Ovarian senescence facilitates both the development of massive hepatic steatosis and the fibrotic progression of liver disease in an experimental overfed zebrafish model. Consistently, estrogen deficiency, by potentiating hepatic inflammatory changes, hastens the progression of disease in a dietary model of nonalcoholic steatohepatitis (NASH) developing in ovariectomized mice fed a high-fat diet. In humans, NAFLD more often affects men; and premenopausal women are equally protected from developing NAFLD as they are from cardiovascular disease. It would be expected that early menarche, definitely associated with estrogen activation, would produce protection against the risk of NAFLD. Nevertheless, it has been suggested that early menarche may confer an increased risk of NAFLD in adulthood, excess adiposity being the primary culprit of this association. Fertile age may be associated with more severe hepatocyte injury and inflammation, but also with a decreased risk of liver fibrosis compared to men and postmenopausal status. Later in life, ovarian senescence is strongly associated with severe steatosis and fibrosing NASH, which may occur in postmenopausal women. Estrogen deficiency is deemed to be responsible for these findings via the development of postmenopausal metabolic syndrome. Estrogen supplementation may at least theoretically protect from NAFLD development and progression, as suggested by some studies exploring the effect of hormonal replacement therapy on postmenopausal women, but the variable impact of different sex hormones in NAFLD (i.e., the pro-inflammatory effect of progesterone) should be carefully considered.

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“…The evidence from RNA-seq analysis of high MR expression in elephant shark ovary and testis ( Figure 6A) suggests that a Prog-MR complex is important in reproductive responses in elephant shark. Of course, Prog also acts as a reproductive steroid in ovary and testis via transcriptonal activation of the PR (66,67). Based on evidence that Prog activates the MR in several ray-finned fishes (24,36,44,46), a Prog-MR complex also may be active in reproductive tissues and other tissues in ray-finned fish, as well as in cartilaginous fish.…”

Section: Role For Elephant Shark Mr In Reproductive Physiologymentioning

confidence: 99%

Transcriptional activation of elephant shark mineralocorticoid receptor by corticosteroids, progesterone, and spironolactone

et al. 2019

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We report the analysis of activation by corticosteroids and progesterone of full-length mineralocorticoid receptor (MR) from elephant shark, a cartilaginous fish belonging to the oldest group of jawed vertebrates. Based on their measured activities, aldosterone, cortisol, 11deoxycorticosterone, corticosterone, 11-deoxcortisol, progesterone and 19-norprogesterone are potential physiological mineralocorticoids. However, aldosterone, the physiological mineralocorticoid in humans and other terrestrial vertebrates, is not found in cartilaginous or rayfinned fishes. Because progesterone is a precursor for corticosteroids that activate elephant shark MR, we propose that progesterone was an ancestral ligand for elephant shark MR. Although progesterone activates ray-finned fish MRs, progesterone does not activate human, amphibian or alligator MRs, suggesting that during the transition to terrestrial vertebrates, progesterone lost the ability to activate the MR. Comparison of RNA-sequence analysis of elephant shark MR with that of human MR suggests that MR expression in the human brain, heart, ovary, testis and other non-epithelial tissues evolved in cartilaginous fishes. Together, these data suggest that progesterone-activated MR may have unappreciated functions in elephant shark ovary and testis.

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Steroid receptors and their ligands: Effects on male gamete functions

Cited by 48 publications

References 130 publications

Sudomotor and vasomotor activity during the menstrual cycle with global heating

Sudomotor and vasomotor activity during the menstrual cycle with global heating

NAFLD as a Sexual Dimorphic Disease: Role of Gender and Reproductive Status in the Development and Progression of Nonalcoholic Fatty Liver Disease and Inherent Cardiovascular Risk

Transcriptional activation of elephant shark mineralocorticoid receptor by corticosteroids, progesterone, and spironolactone

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