Steroid profiles of healthy individuals

Pfeifer, Peter; Spiteller, Gerhard

doi:10.1016/s0378-4347(00)80064-x

Cited by 25 publications

(2 citation statements)

References 17 publications

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“…The excretion of dehydroepiandrosterone is < l .0 mg/ 24 h in normal women, with a ränge from 0.1 to 1.0 mg/24 h. Elevation of dehydroepiandrosterone has been observed in stress in normal subjects (22). This raises the question of whether the elevations of dehydroepiandrosterone noted in our hirsute females were manifestations of stress.…”

Section: Discussionmentioning

confidence: 44%

Fractionation of Urinary 17-Ketosteroids by Gas Chromatography: A Neglected Procedure in the Assessment of Hyperandrogenicity in the Hirsute Female

Shapiro

Zelefsky²,

Chayen³

et al. 1989

Clinical Chemistry and Laboratory Medicine

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17-Ketosteroids were determined by gas chromatography in twenty four-hour urine samples from 62 hirsute females. The method permitted the determination of androsterone (A), aetiocholanolone (E) and dehydroepiandrosterone (D). Elevated concentrations of one or more of these metabolites were detected in 81% of the samples.Two main patterns of hyperandrogenicity were observed: 1) Hyper A + E (27%) and 2) Hyper A (26%); Elevated AD, AED, D, ED or E were less common, but in total these patterns comprised another 28%.The plasma testosterone and total urinary 17-ketosteroid concentrations were elevated in only 21% and 23% of the samples, respectively. _ Thirty two out of 33 patients with elevated urine metabolites showed significant suppression following dexamethasone administration (2 mg/day during 6 days). Thus, dexamethasone suppressable hyperandrogenicity was predomimant in this group of hirsute females. Elevations of urinary androsterone and aetiocholanolone are probably contingent on the relative activities of 5 -and Sß-reductases 1 ) in the presence of increased androstenedione secretion. Elevations of urinary dehydroepiandrosterone suggest decreased adrenal cortical 3ß-hydroxysteroid dehydrogenase 1 ) activity. Thus, fractionation of urinary 17-ketosteroids seems to be an effective test in the evaluation of hirsutism.

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Section: Discussionmentioning

confidence: 44%

Fractionation of Urinary 17-Ketosteroids by Gas Chromatography: A Neglected Procedure in the Assessment of Hyperandrogenicity in the Hirsute Female

Shapiro

Zelefsky²,

Chayen³

et al. 1989

Clinical Chemistry and Laboratory Medicine

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“…Based on this approach, a method for the sensitive quantification of urinary testosterone (T) and epitestosterone (E) was established, and the ratio between both urinary concentrations (T/E) was introduced as a robust indicative marker for T administrations 2 . Also the general concept of urinary steroid profiles dates back to this time albeit, in the beginning, mainly abundant steroids were considered here to evaluate the health status of individuals encompassing determinations of androsterone (A), etiocholanolone (ETIO) and dehydroepiandrosterone (DHEA) 3 4 .…”

Section: Introductionmentioning

confidence: 99%

Current Insights into the Steroidal Module of the Athlete Biological Passport

et al. 2021

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For decades, the class of anabolic androgenic steroids has represented the most frequently detected doping agents in athletes’ urine samples. Roughly 50% of all adverse analytical findings per year can be attributed to anabolic androgenic steroids, of which about 2/3 are synthetic exogenous steroids, where a qualitative analytical approach is sufficient for routine doping controls. For the remaining 1/3 of findings, caused by endogenous steroid-derived analytical test results, a more sophisticated quantitative approach is required, as their sheer presence in urine cannot be directly linked to an illicit administration. Here, the determination of urinary concentrations and concentration ratios proved to be a suitable tool to identify abnormal steroid profiles. Due to the large inter-individual variability of both concentrations and ratios, population-based thresholds demonstrated to be of limited practicability, leading to the introduction of the steroidal module of the Athlete Biological Passport. The passport enabled the generation of athlete-specific individual reference ranges for steroid profile parameters. Besides an increase in sensitivity, several other aspects like sample substitution or numerous confounding factors affecting the steroid profile are addressed by the Athlete Biological Passport-based approach. This narrative review provides a comprehensive overview on current prospects, supporting professionals in sports drug testing and steroid physiology.

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Kombination chromatographischer Trennmethoden mit der Massenspektrometrie – ein modernes Verfahren zur Stoffwechseluntersuchung

Spiteller

1985

Angew. Chem.

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Die in den letzten Jahrzehnten entwickelten potenten Trennverfahren, insbesondere die Glaskapillargaschromatographie (GC) und die Fliissigkeitschromatographie (High Performance Liquid Chromatography, HPLC) konnen uns in Kombination rnit empfindlichen Nachweismethoden wie der Massenspektrometrie (MS) neue Einblicke in Stoffwechselprozesse gewahren. Damit wird die Forschung auf einem Gebiet, das lange Zeit als nahezu abgeschlossen galt, neu belebt. Neue Perspektiven eroffnen sich auch fur Untersuchungen uber die Metabolisierung von Nahrungs-, GenuD-und Arzneimitteln im Korper sowie uber die Art, wie sich der Organismus schadlicher Stoffe entledigt und wie und wann diese Verbindungen in das korpereigene Stoffwechselgeschehen eingreifen.

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Steroid profiles of healthy individuals

Cited by 25 publications

References 17 publications

Fractionation of Urinary 17-Ketosteroids by Gas Chromatography: A Neglected Procedure in the Assessment of Hyperandrogenicity in the Hirsute Female

Fractionation of Urinary 17-Ketosteroids by Gas Chromatography: A Neglected Procedure in the Assessment of Hyperandrogenicity in the Hirsute Female

Current Insights into the Steroidal Module of the Athlete Biological Passport

Kombination chromatographischer Trennmethoden mit der Massenspektrometrie – ein modernes Verfahren zur Stoffwechseluntersuchung

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