“…The finding that echidna adrenals produce aldosterone underlines the essential similarity of adrenal cortical function in this species which survives adrenalectomy, compared with most other mammalia which do not. The American opossum provides a parallel case, since it, too, may survive adrenalectomy (Silvette & Britton, 1936;Britton & Silvette, 1937;Hartman, Smith & Lewis, 1943) and produces a full complement of adrenal cortical steroids (Brownell, Beck & Besch, 1967;Johnston, Davis & Hartroft, 1967). Although the capacity to produce aldosterone was shown in the present experiments, Reid (1971) demonstrated renin activity only in echidnas that were sodium depleted.…”