Steroid Premedication and Monoclonal Antibody Therapy: Should We Reconsider?
Emma-Anne Karlsen,
Euan Walpole,
Fiona Simpson
Abstract:Opinion statementMonoclonal antibody (mAb) therapy is now considered a main component of cancer therapy in Australia. Although traditionally thought of as pure signalling inhibitors, a large proponent of these medications function through antibody-dependent cell-mediated cytotoxicity (ADCC). Currently, most protocols and institutional guidelines for ADCC-mediated mAbs promote the use of corticosteroids as premedication: this is implemented to reduce infusion-related reactions (IRRs) and antiemesis prophylaxis … Show more
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