Steroid modulation of the expression of growth factors and oncogenes in breast cancer

Ks, McCarty

doi:10.1007/978-1-4615-3940-7_9

Cited by 2 publications

(2 citation statements)

References 95 publications

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“…For example, the molecular mechanisms that steroid hormones use to affect cell differentiation, proliferation, and growth remain ill-defined. Furthermore, it is unknown if gonadal hormones, such as estradiol, act directly on cells or whether other hormone-stimulated autocrine and paracrine growth factors, such as IGF-I, IGF-II, TGF-oo, TGF-p, EGF, and FGF (Dickson and Lippman, 1988;McCarty and McCarty, 1991) are responsible for modulating cell function.…”

Section: Hormones and Cells Of The Periodontiummentioning

confidence: 99%

Sex Steroid Hormones and Cell Dynamics in the Periodontium

Mariotti

1994

Critical Reviews in Oral Biology & Medicine

184

248

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The biological changes that occur in tissues of the periodontium during puberty, the menstrual cycle, pregnancy, menopause, and oral contraceptive use have heightened interest in the relationship between sex steroid hormones and periodontal health. These clinical observations coupled with tissue specificity of hormone localization, identification of hormone receptors, as well as the metabolism of hormones have strongly suggested that periodontal tissues are targets for androgens, estrogens, and progestins. The etiologies of periodontal endocrinopathies are diverse; nonetheless, periodontal pathologies may be a consequence of the actions and interactions of sex steroid hormones on specific cells found in the periodontium.

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Section: Hormones and Cells Of The Periodontiummentioning

confidence: 99%

Sex Steroid Hormones and Cell Dynamics in the Periodontium

Mariotti

1994

Critical Reviews in Oral Biology & Medicine

184

248

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“…In the presence of inflammation, alterations in the metabolism of sex steroid hormones (24,25,27,135,136,200) and in the number of hormone receptors (175,178,198) have been noted in cellular elements. Future studies will need to define whether the actions of gonadal hormones directly affect periodontal cells or whether other hormone-stimulated autocrine and paracrine growth factors are responsible for modulating cell function (20,114).…”

Section: Sex Steroid Hormones and Cells Of The Periodontiummentioning

confidence: 99%

Endocrinology of sex steroid hormones and cell dynamics in the periodontium

Mariotti¹,

Mawhinney²

2012

Periodontology 2000

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Numerous scientific studies assert the existence of hormone-sensitive periodontal tissues. Tissue specificity of hormone localization, identification of hormone receptors and the metabolism of hormones are evidence that periodontal tissues are targets for sex steroid hormones. Although the etiologies of periodontal endocrinopathies are diverse, periodontal pathologies are primarily the consequence of the actions and interactions of sex steroid hormones on specific cells found in the periodontium. This review provides a broad overview of steroid hormone physiology, evidence for the periodontium being a target tissue for sex steroid hormones and theories regarding the roles of sex steroid hormones in periodontal pathogenesis. Using this information, a teleological argument for the actions of steroid hormones in the periodontium is assessed.

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Steroid modulation of the expression of growth factors and oncogenes in breast cancer

Cited by 2 publications

References 95 publications

Sex Steroid Hormones and Cell Dynamics in the Periodontium

Sex Steroid Hormones and Cell Dynamics in the Periodontium

Endocrinology of sex steroid hormones and cell dynamics in the periodontium

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