Steroid induced rare bipolar mood disorder

Mazumdar, P.K.; Najib, MA; Varma, S. L.

doi:10.1016/0924-9338(96)80305-1

Cited by 3 publications

(2 citation statements)

References 4 publications

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“…In adults, there have been reports of the successful use of haloperidol [1,55,61], olanzapine [37], risperidone [52], lithium [46,78,86], valproic acid [44], fluvoxamine [22,91]. Others have used multidrug combinations [26,33,34].…”

Section: Treatmentmentioning

confidence: 99%

Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

Hochhauser

Lewis²,

Kamen

et al. 2005

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Despite their therapeutic utility, children may experience emotional and behavioral side effects from steroids during treatment for leukemia. However, clinical manifestations and treatment options have rarely been described in the pediatric literature. The aim of this current paper is to address this knowledge gap via four brief case examples and a review of the literature. In addition, we review recent data to indicate how concurrent use of antifolates may place these children at particular risk for adverse psychological reactions.

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Section: Treatmentmentioning

confidence: 99%

Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

Hochhauser

Lewis²,

Kamen

et al. 2005

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“…Haloperidol’s use to treat steroid-induced psychiatric symptoms is well documented. 13,37-39 Haloperidol is also known to have significantly higher effectiveness compared with other antipsychotics for controlling the positive symptoms of schizophrenia. 36 Despite a proven record of success, haloperidol should not be universally or arbitrarily prescribed in the management of steroid-induced psychosis, because of its known adverse event profile, as documented in the case reported by Silva and Tolstunov.…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Management of Steroid-Induced Psychosis: A Review of Patient Cases

Huynh

Reinert

2020

Journal of Pharmacy Technology

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Objective: To review the efficacy and safety of medications used in the management of steroid-induced psychosis. Data Sources: A comprehensive literature search was conducted using PubMed, MEDLINE, ProQuest, and Scopus between May and October 2020 using the following search terminology: “steroid-induced psychosis” OR “corticosteroid-induced psychosis.” Study Selection and Data Extraction: Definitive cases, as defined by the Diagnostic and Statistical Manual of Mental Disorders, 5th edition, were included in this review. Geriatric patients >65 years of age, those with a confounding neurological condition such as a traumatic brain or spinal cord injury, or those with active malignancy were excluded. Data Synthesis: A total of 13 patient cases were included in this review, representing 8 male patients and 5 female patients. The mean age at symptom presentation was 42.5 years. Six patients presented with delusions, 5 presented with hallucinations, and 2 presented with both manifestations; 12 patients were managed with an antipsychotic, with haloperidol being the most commonly prescribed, followed by risperidone. One patient was managed with lithium and clonazepam alone. All patients returned to their psychological baseline upon the discontinuation or decreased dose of steroids in combination with Pharmacological intervention, though the time to resolution of symptoms varied significantly. No notable adverse drug events associated with treatments were reported. Conclusions: Steroid-induced psychosis is a serious adverse effect of corticosteroid therapy; however, management strategies that combine a dose reduction or elimination of steroids, in combination with an antipsychotic medication, are effective in resolving this syndrome.

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Steroid-induced mania in a patient with previously well-controlled organic bipolar 1-like affective disorder secondary to acquired brain injury: case report and literature review

King,

Elliott,

Pitman

2024

Discov Ment Health

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Steroid-induced neuropsychiatric sequelae are common, and pose significant risks to people usually receiving glucocorticoids in the context of physical illness. Steroid-induced mania and hypomania are the most common of the acute complications, yet despite great progress in understandings in neurophysiology there are no recent studies which review the factors which might predict who will experience this severe complication, nor are there consensus guidelines on management. We report the unusual case of a woman in her 50s admitted to a psychiatric unit with steroid-induced mania despite compliance with two mood stabilisers, several days after the administration of a Dexamethasone and Docetaxel chemotherapy regime adjunctive to lumpectomy for breast cancer. She had previously been diagnosed with an organic affective disorder (with classical bipolar 1 pattern) following severe ventriculitis related to ventricular drain insertion for obstructive hydrocephalus secondary to a colloid cyst. She had no psychiatric illness before this brain injury, but has a maternal history of idiopathic bipolar 1 affective disorder. Her episode of steroid-induced mania resolved following use of sedative medications, continuation of her existing mood stabilisers, and reductions of the steroid dosing in collaboration with her oncology team, which also protected her from further manic relapses during continued chemotherapy. Established mental illness, a family history, and acquired brain injury may reflect risk factors for steroid-induced mania through currently unclear pathways. Future epidemiological studies could better confirm these observations, and basic neuroscience may look to further explore the role of extrinsic glucocorticoids in the pathophysiology of affective disorders.

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Steroid induced rare bipolar mood disorder

Cited by 3 publications

References 4 publications

Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

Steroid-induced alterations of mood and behavior in children during treatment for acute lymphoblastic leukemia

Pharmacological Management of Steroid-Induced Psychosis: A Review of Patient Cases

Steroid-induced mania in a patient with previously well-controlled organic bipolar 1-like affective disorder secondary to acquired brain injury: case report and literature review

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