Steroid-Induced Osteonecrosis in Dermatology

Abstract

Dermatologists must exercise a high degree of clinical suspicion and warn patients about steroid-related risks and conditions for follow-up.

Management of imported cutaneous larva migrans: A case series and mini-review

“…In nonhospitalized patients, penicillins and fluoroquinolones (both of which were used to treat CLM in this series) carried a 2.7-to 5.5-fold increased odds of Clostridium difficile colitis compared to no antibiotic exposure [20]. Prednisone, also used by patients in this series, leads to myriad adverse sequelae including hypertension, dyslipidemia, hyperglycemia, myopathy, dysphoria, osteoporosis, idiosyncratic osteonecrosis, and immunosuppression when used chronically and at high doses [21,22]. Although short courses of high-dose steroids (ie, prednisone 40 mg per day  5 days) may provide short-term symptomatic relief in CLM, prolonged use should be avoided due to the serious adverse event profile of corticosteroids, and the much more benign profile of targeted therapies such as albendazole or ivermectin.…”

Drug micronization technique: new possibilities of topical corticosteroids in dermatology

“…Эти заболевания отличаются по патогенезу, клиническим проявлениям, но их объединяет необходимость супрессивного воздействия на клетки иммунной системы, ассоциированные с кожей. При применении топических ГКС отмечается локальное повышение их концентрации в зоне воспалительного процесса, за счет чего ГКС не оказывают супрессорного действия как на центральную иммунную систему, так и на другие системы организма, что позволяет избежать тяжелых побочных эффектов [8].…”

Chemical and Radiation-Associated Jaw Lesions

“…Smoking, alcohol abuse and comorbid conditions like osteoporosis and systemic lupus erythematosus predispose patients to steroid induced osteonecrosis. 37 …”