Steroid-Induced Diabetic Ketoacidosis.

Alavi, Iltifat A.

doi:10.7326/0003-4819-72-5-787_1

Cited by 3 publications

(7 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…DKA also occurs in subjects with both type 1 and 2 diabetes due to relative insulin deficiency at the onset of acute illness, e.g. infections, myocardial infarction, congestive heart failure, acute pancreatitis as well as during pregnancy and following steroid therapy [1][2][3][4][5][6]. Recently, we reported a subject who presented with DKA as the initial manifestation of Cushing Disease caused ACTH secreting pituitary adenoma with total remission of diabetes following trans sphenoidal resection (7).…”

Section: Discussionmentioning

confidence: 99%

“…DKA is a serious and potentially life threatening complication. Predisposing factors include new-onset type 1 diabetes, insulin withdrawal and onset of acute illness [1][2][3][4][5][6]. In this report, we describe 2 subjects who presented DKA as initial manifestation of acromegaly secondary to growth hormone producing pituitary adenomas and total remission following resection in one and surgery followed by treatment with Sandostatin in the other…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Cases of diabetic ketoacidosis as an initial presentation of acromegaly

Kabadi¹

2017

Integr Obesity Diabetes

View full text Add to dashboard Cite

Diabetic ketoacidosis (DKA) is a complication of diabetes mellitus especially of type 1 variety often requiring hospitalization. Herein we report 2 subjects with Acromegaly who presented with DKA as the initial manifestation. In one subject, total remission from diabetes occurred following successful resection of growth hormone secreting pituitary adenoma localized to pituitary fossa without onset of hypopituitarism. In the other subject, total remission of diabetes ensued only after administration of somatostatin (Sandostatin LAR) once a month for 6 months since a complete resection of pituitary adenoma could not be performed due to suprasellar extension and hypopituitarism requiring treatment persisted after surgery.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cases of diabetic ketoacidosis as an initial presentation of acromegaly

Kabadi¹

2017

Integr Obesity Diabetes

View full text Add to dashboard Cite

show abstract

“…The development of ketoacidosis in the setting of glucocorticoids is uncommon but has been previously described [2,4,5]. Alavi et al [2] described the onset of glucocorticoid-induced DKA in 5 patients receiving glucocorticoids for collagen vascular disease. The reported doses of prednisone ranged between 30 to 120 mg daily.…”

Section: Discussionmentioning

confidence: 99%

“…Ketoacidosis occurs when there is insufficient insulin for carbohydrate metabolism, with the net effect being a release of Free Fatty Acids (FFAs) from adipose tissue which is converted into ketone bodies [2]. Insulin and glucocorticoids play opposing roles in the mobilisation of FFA.…”

Section: Discussionmentioning

confidence: 99%

“…However, their use is accompanied by side effects including hyperglycaemia. The mechanisms are multifactorial, and include opposition of insulin action, augmentation of hepatic gluconeogenesis and inhibition of glucose uptake in adipose tissue [1,2]. L-asparaginase is an agent used to treat Acute Lymphoblastic Leukaemia (ALL) which is reported to cause hyperglycaemia in approximately 10% of patients [3].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation