Steroid-induced cataract

Samadi, Abbas

doi:10.1016/b978-0-7020-2983-7.00033-4

Cited by 2 publications

(2 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Steroid‐induced cataract can be utilised as a diabetic model given the ability of steroids to increase plasma glucose levels. Additionally, corticosteroids could induce cataract by inhibiting Na/K‐ATPase, increasing cation permeability, inhibiting glucose 6‐phopshphate dehydrogenase and forming Schiff's bases with lens crystallins [48]. This can be induced by injection of steroids into the vitreous body or by incubation of the lens in a medium containing prednisolone [33]…”

Section: Current Strategies For Experimental Cataractmentioning

confidence: 99%

“…Additionally, corticosteroids could induce cataract by inhibiting Na/K-ATPase, increasing cation permeability, inhibiting glucose 6-phopshphate dehydrogenase and forming Schiff's bases with lens crystallins. [48] This can be induced by injection of steroids into the vitreous body or by incubation of the lens in a medium containing prednisolone. [33] Experimental cataract induced by a single injection or incubating the whole lens in a culture medium containing sodium selenite has been reported to show morphological and biochemical changes in the lens similar to those found in with age-related nuclear cataract A sharp decline in GSH, an increase in GSSG, a decrease in NADPH and increase in NADP + and loss of protein thiol typically take place rapidly with an increase in selenite levels in the lens.…”

Section: Physical Changesmentioning

confidence: 99%

See 1 more Smart Citation

Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens

Abdelkader

Alany

Pierscionek

2015

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

Objectives The search for anticataract drugs has been continuing for decades; some treatments no longer exist but antioxidants are still of much interest. Key findings The primary function of the human lens, along with the cornea, is to refract light so that it is correctly focused onto the retina for optimum image quality. With age, the human lens undergoes morphological, biochemical and physical changes leading to opacification. Age-related or senile cataract is one of the main causes of visual impairment in the elderly; given the lack of access to surgical treatment in many parts of the world, cataract remains a major cause of sight loss. Surgical treatment is the only means of treating cataract; this approach, however, has limitations and complications. Summary This review discusses the anatomy and physiology of the lens and the changes that are understood to occur with ageing and cataract formation to identify potential areas for effective therapeutic intervention. Experimental techniques and agents used to induce cataract in animal models, the advantages and disadvantages of potential pharmacological treatments specific barriers to delivery of exogenous antioxidants to the lens and the prospects for future research are discussed.

show abstract

Section: Current Strategies For Experimental Cataractmentioning

confidence: 99%

Section: Physical Changesmentioning

confidence: 99%

Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens

Abdelkader

Alany

Pierscionek

2015

Journal of Pharmacy and Pharmacology

View full text Add to dashboard Cite

show abstract

Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives

Gaballa

Kompella

El-Garhy

et al. 2020

Drug Deliv. and Transl. Res.

139

114

View full text Add to dashboard Cite

Corticosteroids remain the mainstay of the treatment for various ocular conditions affecting the ocular surface, anterior and posterior segments of the eye due to their anti-inflammatory, anti-oedematous and anti-neovascularization properties. Prednisolone, prednisolone acetate, dexamethasone, triamcinolone acetonide, fluocinolone acetonide, and loteprednol etabonate are amongst the most widely used ophthalmic corticosteroids. Corticosteroids differ in their activity and potency in the eye due to their inherent pharmacological and pharmaceutical differences.Different routes and regimens are available for ocular administration of corticosteroids. Conventional topical application to the eye is the route of choice when targeting diseases affecting the ocular surface and anterior segment, while periocular, intravitreal, and suprachoroidal injections can 3 be potentially effective for posterior segment diseases. Corticosteroid-induced intraocular pressure elevation and cataract formation remain the most significant local risks following topical as well as systemic corticosteroid administration. Invasive drug administration via intracameral, subconjunctival and intravitreal injection can enhance ocular bioavailability and minimize dose and dosing frequency of administration, yet may exacerbate ocular side effects of corticosteroids. This review provides a critical appraisal of the ophthalmic uses of corticosteroid, routes of administration, drug delivery fundamentals and novel ocular implantable steroids delivery systems, factors influencing side effects and future perspectives for ocular corticosteroid therapy.

show abstract

Steroid-induced cataract

Cited by 2 publications

References 77 publications

Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens

Age-related cataract and drug therapy: opportunities and challenges for topical antioxidant delivery to the lens

Corticosteroids in ophthalmology: drug delivery innovations, pharmacology, clinical applications, and future perspectives

Contact Info

Product

Resources

About