Steroid hormone receptors and long term survival in invasive ovarian cancer

Münstedt, Karsten; Steen, J. A.; Knauf, A.G.; Büch, Thomas; Georgi, Richard von; Franke, Folker E.

doi:10.1002/1097-0142(20001015)89:8<1783::aid-cncr19>3.0.co;2-d

Cited by 81 publications

(77 citation statements)

References 32 publications

(19 reference statements)

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“…Moreover, estrogen induces ovarian papillary neoplasms in several species, including dogs (Jabara 1962), rabbits (Bai et al 2000), and pigs (Silva et al 1998). Expression of ESR even at low levels has been associated with an earlierstage, higher tumor differentiation and better prognosis (Geisler et al 1996, Munstedt et al 2000. These in vitro and in vivo studies support the notion that estrogen plays a significant part in ovarian tumorigenesis by regulating the genes underlying tumor cell immortalization and transformation.…”

Section: Regulation Of Telomerase Activity By Estrogenmentioning

confidence: 89%

Telomerase in the ovary

Liu¹,

Li²

2010

Reproduction

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Telomerase, an enzyme complex that binds the chromosome ends (telomeres) and maintains telomere length and integrity, is present in germ cells, proliferative granulosa cells, germline stem cells, and neoplastic cells in the ovary, but it is absent in differentiated or aged cells. Activation of telomerase in the ovary underpins both benign and malignant cell proliferation in several compartments, including the germ cells, membrana granulosa, and the ovarian surface epithelium. The difference in telomerase operation between normal and abnormal cell proliferations may lie in the mechanisms of telomerase activation in a deregulated manner. Recent studies have implicated telomerase activity in ovarian cancer as well as oogenesis and fertility. Inhibition of telomerase and the shortening of telomeres are seen in occult ovarian insufficiency. Studies of how telomerase operates and regulates ovary development may provide insight into the development of both germ cells for ovarian reproductive function and neoplastic cells in ovarian cancer. The current review summarizes the roles of telomerase in the development of oocytes and proliferation of granulosa cells during folliculogenesis and in the process of tumorigenesis. It also describes the regulation of telomerase by estrogen in the ovary.

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Section: Regulation Of Telomerase Activity By Estrogenmentioning

confidence: 89%

Telomerase in the ovary

Liu¹,

Li²

2010

Reproduction

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“…However, concerning the prognostic role the results were discordant. Several groups report a prognostic effect of progesterone receptor, but not of ER (Kommoss et al 1992, Münstedt et al 2000, Hornung et al 2004, Lee et al 2005. Some groups reported a positive prognostic effect of ER expression measured by immunohistochemistry (Isola et al 1990, Høgdall et al 2007, while other studies did not find any prognostic effect (Scambia et al 1995, Lu et al 2006.…”

Section: Discussionmentioning

confidence: 99%

Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: determination by kinetic PCR in formalin-fixed paraffin-embedded tissue

Darb‐Esfahani

Wirtz

Sinn³

et al. 2009

Endocrine-Related Cancer

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Epidemiological and cell culture studies indicate that ovarian carcinoma growth is dependent on estrogen stimulation. However, possibly due to the lack of a reliable biomarker that helps to select patients according to prognostically relevant estrogen receptor (ER) levels, clinical trials using anti-estrogenic therapeutics in ovarian carcinoma have had inconsistent results. Therefore, we tested if ER expression analysis by a quantitative method might be useful in this regard in formalinfixed paraffin-embedded (FFPE) tissue. In a study group of 114 primary ovarian carcinomas expression of estrogen receptor 1 (ESR1) mRNA was analyzed using a new method for RNA extraction from FFPE tissue that is based on magnetic beads, followed by kinetic PCR. The prognostic impact of ESR1 mRNA expression was investigated and compared to ERa protein expression as determined by immunohistochemistry. In univariate survival analysis the expression level of ESR1 mRNA was a significant positive prognostic factor for patient survival (hazard ratio (HR) 0.230 (confidence interval (CI) 0.102-0.516), PZ0.002). ERa protein expression was correlated to ESR1 mRNA expression (PZ0.0001); however, ERa protein expression did not provide statistically significant prognostic information. In multivariate analysis, ESR1 mRNA expression emerged as a prognostic factor, independent of stage, grade, residual tumor mass, age, and ERa protein expression (HR 0.227 (CI 0.078-0.656), PZ0.006). Our results indicate that the determination of ESR1 levels by kinetic PCR may be superior to immunohistochemical methods in assessment of biologically relevant levels of ER expression in ovarian carcinoma, and is feasible in routinely used FFPE tissue.

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“…This provides an insight into the cellular mechanisms of regulation of receptor tyrosine-kinase signaling pathway. PR-positive tumors are associated with an improved patient survival (17).…”

Section: Resultsmentioning

confidence: 99%

Simultaneous Suppression of Epidermal Growth Factor Receptor and c-erbB-2 Reverses Aneuploidy and Malignant Phenotype of a Human Ovarian Carcinoma Cell Line

Pack

Alper²,

Stromberg

et al. 2004

Cancer Research

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Coexpression of epidermal growth factor receptor (EGFR) and cerbB-2 in 47-68% of ovarian cancer cells indicate their strong association with tumor formation. We examined the effects of simultaneous antisenseor immunosuppression of EGFR and c-erbB-2 expression on the invasive phenotype, aneuploidy, and genotype of cultured human ovarian carcinoma cells (NIH:OVCAR-8). We report here that suppression of both EGFR and c-erbB-2 results in regression of aneuploidy and genomic imbalances in NIH:OVCAR-8 cells, restores a more normal phenotype, and results in a more normal gene expression profile. Combined with cytogenetic analysis, our data demonstrate that the regression of aneuploidy is due to the selective apoptosis of double antisense transfected cells with highly abnormal karyotype.

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Steroid hormone receptors and long term survival in invasive ovarian cancer

Cited by 81 publications

References 32 publications

Telomerase in the ovary

Telomerase in the ovary

Estrogen receptor 1 mRNA is a prognostic factor in ovarian carcinoma: determination by kinetic PCR in formalin-fixed paraffin-embedded tissue

Simultaneous Suppression of Epidermal Growth Factor Receptor and c-erbB-2 Reverses Aneuploidy and Malignant Phenotype of a Human Ovarian Carcinoma Cell Line

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