Steroid hormone concentration profiles in healthy intact and neutered dogs before and after cosyntropin administration

Frank, Linda A.; Rohrbach, Barton W; Bailey, E M; West, Joe; Oliver, Jack W.

doi:10.1016/s0739-7240(02)00204-7

Cited by 77 publications

(103 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In a previous study, intact male dogs had lower concentrations of [cortisol] than did castrated males, intact females, and spayed females 17. In our study, we unexpectedly found that [cortisol] was significantly higher in males than in females.…”

Section: Discussionsupporting

confidence: 48%

Biological Variability in Serum Cortisol Concentration Post‐adrenocorticotropic Hormone Stimulation in Healthy Dogs

Gal

Weidgraaf

Bowden

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

BackgroundThe ACTH stimulation has low sensitivity for the diagnosis of hypercortisolism possibly as a result of biological and analytical variability.Hypothesis/ObjectivesTo report the components of biological and analytical variability in serum cortisol concentration post‐ACTH stimulation ([cortisol]) in healthy dogs.AnimalsFourteen healthy harrier hound dogs.MethodsThe data were extracted from a separate, prospective, randomized, double‐blinded, controlled discovery study in which dogs treated with vehicle control and 4 different doses of cortisone acetate (CA) for 7 days had an ACTH stimulation test performed to confirm the dose‐dependent effect of CA. The index of individuality (IoI), the critical difference between sequential measurements (C D), and the number of measurements required to assess the homeostatic set point (HSP) of [cortisol] with confidence intervals (CI) of 90 and 95% were estimated.ResultsThe IoI was equal to 1.1 and the C D was 3.3 μg/dL (92 nmol/L). The number of measurements required to assess the HSP of [cortisol] with CI of 90 and 95% were 3 and 15, respectively. Additionally, mean [cortisol] was higher in males than in females (13.3 ± 4 μg/dL [366 ± 114 nmol/L] vs. 11.5 ± 2.5 μg/dL [318 ± 65 nmol/L], respectively; P = .046). As expected, treatment with CA resulted in a dose‐dependent suppression of [cortisol].Conclusions and Clinical ImportanceFalse‐negative test results in hypercortisolism could occur when [cortisol] is outside of the individual's HSP and within the reference interval. The large C D emphasizes the importance of assessing clinically relevant parameters in the diagnosis and monitoring of HC.

show abstract

Section: Discussionsupporting

confidence: 48%

Biological Variability in Serum Cortisol Concentration Post‐adrenocorticotropic Hormone Stimulation in Healthy Dogs

Gal

Weidgraaf

Bowden

et al. 2017

Veterinary Internal Medicne

View full text Add to dashboard Cite

show abstract

“…Increases in testosterone and vasopressin have been reported to be related to physical activity (Campbell et al 1982, Wade 1984, which may explain the fact that the increases had already started before the gunshot test took place. In addition, it has been reported that stimulation with ACTH does not increase testosterone concentrations in male dogs, but does in females (Frank et al 2003), which may be an additional explanation as to why testosterone levels did not change further in response to the tests in this study.…”

Section: Figurementioning

confidence: 44%

“…In dogs, cortisol has been found to increase during transportation (Kuhn et al 1991, Bergeron et al 2002 and shock (Dess et al 1983), when exposed to sound blasts (Beerda et al 1998), and during social and spatial restriction (Beerda et al 1999). In one study, it was reported that when ACTH was administered to dogs not only cortisol but also progesterone increased markedly in both males and females (Frank et al 2003). This suggests that progesterone may be a further indicator of activation of the hypothalamic-pituitary axis.…”

Section: Introductionmentioning

confidence: 99%

Physiological reactions to fear provocation in dogs

Hydbring-Sandberg

Walter²,

Höglund³

et al. 2004

Journal of Endocrinology

View full text Add to dashboard Cite

Fear is a common behavioral problem in dogs. In this paper, we studied the association between behavioral and physiological responses in two potentially fear-eliciting situations. The aim was to establish whether it is possible to separate dogs of the collie breed that are fearful of floors and gunshots from those that are not by studying changes in heart rate and hematocrit, plasma cortisol, progesterone, testosterone, vasopressin, and -endorphin concentrations. Thirteen privately owned male dogs of the collie breed were studied during a floor test, using different types of floors, and a subsequent gunshot test. Seven of the dogs were identified as being fearful of floors and six were declared as fearless. Out of the 13 dogs, seven were fearful of gunshots and six were fearless of gunshots. Since fear of floors did not always occur concomitantly with fear of gunshots, there were consequently four different groups of dogs. The heart rate increased during the floor test in all groups, but dogs that were fearful of floors had higher heart rates than dogs that were fearless of floors. Dogs that were fearful of gunshots had higher heart rates, higher hematocrit levels and higher plasma concentrations of cortisol, progesterone, vasopressin, and -endorphins during the gunshot test than did dogs that were found to be fearless of gunshots. Plasma cortisol and progesterone increased drastically during the gunshot test in dogs identified as being fearful of gunshots. In fearful dogs, the testosterone concentration increased after completion of the floor test and before the gunshot test started, but there were no significant differences in testosterone between the groups. Since dogs fearful of gunshots had increased levels of several physiological parameters, the results demonstrated that this fear is a serious stress for the individual, a fear which it is possible to register with physiological variables.

show abstract

“…Ten castrated male and 4 spayed female dogs were included in the present study. Gonadectomy does not generally affect thyroid or adrenocortical function, although slight differences between gonadectomized and intact dogs have been reported [6,10]. The mechanism underlying the adipokine and thyroid hormone associations in canines requires further study.…”

Section: Discussionmentioning

confidence: 96%

Leptin, adiponectin levels, and thyroid hormones in normal and obese dogs

Lee¹,

Lim²,

Park³

et al. 2014

Korean Journal of Veterinary Research

View full text Add to dashboard Cite

: The present study compared leptin, adiponectin, and thyroid hormone concentrations in normal and obese dogs, and evaluated the association between leptin and adiponectin concentrations and thyroid function. The serum leptin, adiponectin, thyroid-stimulating hormone (TSH), total thyroxine (tT4), free thyroxine (fT4), triiodothyronine (T3), and cortisol concentrations were measured in 18 normal dogs (body condition score [BCS]: 4-5/9) and 16 obese dogs (BCS: 8-9/9). Leptin and T3 concentrations were higher in the obese group than the normal weight group (p < 0.01 and p < 0.05, respectively). In both groups, the T3 and leptin concentrations were correlated (r = 0.370, p < 0.05), as were the TSH and fT4 and adiponectin concentrations (r = −0.373, p < 0.05 and r = 0.369, p < 0.05, respectively). In the normal weight group, the TSH and fT4 concentrations were correlated with the adiponectin concentrations (r = − 0.528, p < 0.05 and r = 0.482, p < 0.05, respectively). The results of the present study suggest that leptin and T3 concentrations are significantly higher in obese dogs than normal weight dogs, and the serum T3 and leptin concentrations are positively correlated.

show abstract

Steroid hormone concentration profiles in healthy intact and neutered dogs before and after cosyntropin administration

Cited by 77 publications

References 19 publications

Biological Variability in Serum Cortisol Concentration Post‐adrenocorticotropic Hormone Stimulation in Healthy Dogs

Biological Variability in Serum Cortisol Concentration Post‐adrenocorticotropic Hormone Stimulation in Healthy Dogs

Physiological reactions to fear provocation in dogs

Leptin, adiponectin levels, and thyroid hormones in normal and obese dogs

Contact Info

Product

Resources

About