Steroid-Decorated Antibiotic Microparticles for Inhaled Anti-Infective Therapy

Tailored Antibiotic Combination Powders for Inhaled Rotational Antibiotic Therapy

“…The operating parameters for spray drying were adapted from Lee et al 27 A smaller spray mesh size (i.e., 5.5 mm) and more dilute solute concentration (i.e., 0.65 wt/vol %) were applied instead, so as to maximize the production of respirable-size particles (i.e., <5 mm). Higher inlet temperature (i.e., 120 C) was also used to generate drier and hence more aerodynamic powders.…”

Inhaled Antibiotics for Gram-Negative Respiratory Infections

“…A novel steroid-antibiotic dry-powder formulation consisting of ciprofloxacin and beclomethasone was developed via spray-drying (115). The combination of ciprofloxacin and beclomethasone showed increased drug release and a high fine-particle fraction compared to those of the individual agents.…”

A novel inhaled multi-pronged attack against respiratory bacteria

“…Hence, this treatment 99 approach is considered useful in the prevention and treatment of 100 resistant bacterial infections (Chernish and Aaron, 2003;Doring 101 et al, 2000;Mouton, 1999;Watkins et al, 1988;Weiss and 102 Lapointe, 1995), and whenever a favorable synergistic effect is 103 achieved, the whole treatment regimen thereby becomes more 104 valuable, as the same killing effect could be obtained at much 105 reduced doses and with fewer side effects (Chernish and Aaron, 106 2003). Although antibiotic combinations are commonly engineered 107 in medicine to broaden the antimicrobial spectrum and generate 108 synergistic effects, combinations of antibiotics with non-antibiotic 109 drugs are increasingly gaining popularity as well (Ejim et al, 2011;110 Heaf et al, 1983;Kalan and Wright, 2011;Lee et al, 2014). These Elmore et al, 1996;Loughlin and Eigen, 1994;Traini 135 and Young, 2009).…”

“…As airway mucus hyper-158 secretion is a common clinical feature of many severe respiratory 159 diseases like asthma, chronic obstructive pulmonary disease 160 (COPD) and cystic fibrosis (CF) (Balsamo et al, 2010;Rogers, 161 2007), the proposed multi-pronged treatment strategy is thus 162 expected to be highly applicable and beneficial to a diverse group 163 of patients (e.g. pneumonia-COPD patients) (Lee et al, 2014). 164 In this work, ciprofloxacin hydrochloride (CIP) and gatifloxacin 165 hydrochloride (GAT) were selected as the synergistic antibiotic pair 166 , while ambroxol hydrochloride (AMB) was chosen 167 for its multi-faceted properties (Paleari et al, 2011) that include 168 quorum quenching (Dong et al, 2007;Hassett et al, 2002;Lu 169 et al, 2010), mucoactivity (Paleari et al, 2011) and pulmonary pro-170 tective effects (Li et al, 2012).…”

“…3 and Table 2. In this work, airflow of 329 60 L/min was used to simulate the reduced inspiratory effort (Lee et al, , 2014. Generally, when 332 the spray-dried powders were delivered individually (as single 333 component systems), their FPFs ranged from being poor to margin-334 ally acceptable.…”