Steroid Control of Pituitary Function

Greep, Roy O.; Jones, I.Chester

doi:10.1016/b978-0-12-571105-0.50010-1

Cited by 47 publications

(33 citation statements)

References 32 publications

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“…The Hoffman & Schwartz (1964, 1965 (Everett, 1961;Peterson, Edgren & Jones, 1964;Kaufman & Rothchild, 1966). Support for this conclusion is afforded by the work of Greep & Jones (1950) (Bennett, Vallance & Vickery, 1968 …”

Section: Introductionsupporting

confidence: 50%

The Synchronization of Ovulation in the Adult Female Rat by Oral Administration of Megestrol Acetate

Bennett¹,

Vallançe²,

Vickery³

1968

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Section: Introductionsupporting

confidence: 50%

The Synchronization of Ovulation in the Adult Female Rat by Oral Administration of Megestrol Acetate

Bennett¹,

Vallançe²,

Vickery³

1968

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“…However, many of these studies have yielded inconsistent results. Greep & Chester-Jones (1950) were not able to detect any changes in total pituitary gonadotrophin content of intact female rats treated with 1 mg of progesterone daily for 45 days. However, Byrnes, Meyer & Finnerty (1951) noted a decrease in total blood gonadotrophin levels in parabiotic rats whose partners received from 0-5 to 1-0 mg of progesterone daily for 10 days.…”

Section: Introductionmentioning

confidence: 96%

The Effect of Progesterone on Serum Luteinizing Hormone Concentrations in the Ewe

McDonald¹,

Clegg²

1967

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“…The ovarian tumours under these experimental conditions result from an irregular interplay of no less than five hormones! In castrated rats receiving daily injections of oestrogen during 45 days control of the gonadotrophic activity of the hypophysis can be achieved by quantities of oestrogen which are not yet sufficient to promote uterine growth (Byrnes, Meyer and Finerty, 1951;Greep and Jones, 1950). We are unable to explain why the hypophysis behaves in experiments with intrasplenic grafts in a manner so different from what has been observed in rats under the related experimental conditions.…”

Section: Unpublished Work Of Iglesias and Mardones)mentioning

confidence: 72%

The Hormonal Background of Ovarian Experimental Tumourigenesis in the Guinea-Pig

Iglesias¹,

Mardones²,

Lipschütz³

1953

Br J Cancer

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THE tumours which appear in the intrasplenic ovarian graft in castrated rats, mice, guinea-pigs or rabbits apparently are due to the uncontrolled gonadotrophic activity of the prehypophysis, the ovarian steroid hormones which normally control hypophysial activity being inactivated during their passage through the liver before reaching the general circulation (Iglesias, Mardones and Lipschutz, 1953). The most striking proof in favour of this explanation is given by the administration of ovarian hormones. When oestrogen is administered the intrasplenic ovarian graft in the castrated guinea-pig offers the aspect of a normal ovary; hemorrhagic follicles and irregular luteal cords or nodules so characteristic of the intrasplenic graft in the guinea-pig fail to appear and seemingly normal corpora lutea are present (Lipschutz, Iglesias, Bruzzone, Humerez and Peinaranda.. 1948). On the other hand, corpora lutea, but also luteomata, are counteracted when progesterone is administered for several months (Mardones, 1948;Iglesias, Lipschutz and Mardones, 1950; Mardones, Bruzzone, Iglesias and Lipschutz, 1951). In mice the ovarian tumours arising in intrasplenic grafts can be prevented when oestrogen or androgen is given (Li and Gardner, 1949).It seemed, at first sight, rather contradictory when it was found that inactivation of oestrogen under these experimental conditions was in general incomplete, as evidenced by the increase of the weight of the uterus and vagina (Bernstorf, 1951), and that granulosa-cell tumours and luteomata may develop in the intrasplenic ovarian graft in castrated rats with persistent oestrus (4 cases described by Lacour. Oberling and Guerin, 1951).In the present paper the question is examined whether ovarian tumourigenesis in experiments of long duration in the guinea-pig presupposes suppression of oestrogenic action in the body. We shall be able to show (1) that this is not the case, and (2) that the hormonal imbalance from which ovarian tumourigenesis under the given experimental conditions derives can, and must, be expressed in quantitative terms.For the purpose of this study the secretory activity of 15 intrasplenic grafts, as listed in Table I of our previous paper (Iglesias, Mardones and Lipschutz, 1953) has been checked by the histological examination of the vaginal mucosa. the uterus and the mammary glands. The material included 8 grafts with luteomata and 7 without lutoomata. A series of 9 experiments is added in which after castration and intrasplenic grafting minute quantities of oestrogen were administered during 26 to 27 months. 15

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Steroid Control of Pituitary Function

Cited by 47 publications

References 32 publications

The Synchronization of Ovulation in the Adult Female Rat by Oral Administration of Megestrol Acetate

The Synchronization of Ovulation in the Adult Female Rat by Oral Administration of Megestrol Acetate

The Effect of Progesterone on Serum Luteinizing Hormone Concentrations in the Ewe

The Hormonal Background of Ovarian Experimental Tumourigenesis in the Guinea-Pig

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