Steroid Components in the Adrenal Venous Blood of Trichosurus Vulpecula (Kerr)

Ic, Jones; Gp, Vinson; Ig, Jarrett; Sharman, G. B.

doi:10.1677/joe.0.0300149

Cited by 27 publications

(14 citation statements)

References 1 publication

(1 reference statement)

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“…It is possible that the high levels of testosterone in the blood represent significant secretion in vivo of testosterone by the adrenal cortex, particularly (if the values for yields of testosterone from pregnenolone and progesterone may be interpreted in this way) from the special zone. This would accord with our earlier work (Chester Jones et al 1964) in which evidence for the secretion of testosterone into the adrenal venous effluent was provided. In the earlier work, it appeared that the testosterone isolated occurred in an unusual conjugated form.…”

Section: Discussionsupporting

confidence: 91%

“…In confirmation of earlier work (Chester Jones et al 1964;Weiss & McDonald, 1966) it seems that the possum adrenal produces both 17a-hydroxycorticosteroids (e.g. cortisol) and 17-deoxycorticosteroids (e.g.…”

Section: Discussionsupporting

confidence: 85%

“…Data are also presented on the concen¬ tration of testosterone in the peripheral blood of this animal. The work follows earlier studies in which cortisol and testosterone (apparently in an unusual conjugated form) were detected in the adrenal venous effluent of this species (Chester Jones, Vinson, Jarrett & Sharman, 1964), and also the studies, in vitro and in vivo, of Weiss & McDonald (1966) and Weiss (1968) who isolated cortisol, corticosterone, aldo¬ sterone and various intermediates from this species.…”

Section: Introductionsupporting

confidence: 65%

“…corticosterone). The yields of cortisol seem very low, particularly in view of the earlier observations in vivo which showed cortisol to be especially prominent (Chester Jones et al 1964;Weiss & McDonald, 1966). One possibility is that cortisol itself may be extensively metabolized by the adrenal cortex (thus pro¬ ducing the very polar products mentioned in the Results section).…”

Section: Discussionmentioning

confidence: 86%

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Functional Zonation of Adrenocortical Tissue in the Brush Possum (Trichosurus Vulpecula)

Vinson¹,

PHILLIPSt²,

Jones³

et al. 1971

Journal of Endocrinology

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The relationship of structure and function in the adrenal gland of the possum Trichosurus vulpecula, has been studied using in-vitro incubation techniques. It was shown that both 17\g=a\-hydroxycorticosteroids and 17-deoxycorticosteroids were produced from radioactive pregnenolone and progesterone, and that these transformations occurred both in the definitive cortex as well as in a special zone of hypertrophied tissue found only in the adult female.In support of earlier findings, it was also shown that the adrenal cortex of the possum has a remarkable capacity to produce C19 steroids (including androstenedione and testosterone) from the radioactive precursors. While most of the transformations occurred with equal efficiency in both types of tissue, the reduction of androstenedione to testosterone seemed to take place more readily in the special hypertrophied zone of the adult female.In studies in vivo, it was found that levels of testosterone in the peripheral blood of the adult female possum were extremely high compared with man. Variations in testosterone levels were not apparently correlated with the stage of the oestrous cycle. The possible pathways by which the adrenal products are synthesized, and their physiological implications are discussed.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 85%

Section: Introductionsupporting

confidence: 65%

Section: Discussionmentioning

confidence: 86%

See 2 more Smart Citations

Functional Zonation of Adrenocortical Tissue in the Brush Possum (Trichosurus Vulpecula)

Vinson¹,

PHILLIPSt²,

Jones³

et al. 1971

Journal of Endocrinology

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“…Those of the common species will be discussed first. Cortisol is the main plasma corticosteroid of the brush-tailed possum (102). The sea lion produces mostly cortisol and corticosterone (103) as well as small amounts of aldosterone.…”

Section: Corticoid Secretions In Mammalsmentioning

confidence: 99%

Steroid production by incubated mouse adrenals

Triller

Birmingham

1965

General and Comparative Endocrinology

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Physiological changes in brushtail possums,Trichosurus vulpecula, transferred from the wild to captivity

Baker

Gemmell

1998

J. Exp. Zool.

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To determine the effect of relocation on the health of possums, the body weights and hormone and immune responses of 11 male and 9 female brushtail possums were monitored following transfer from the environs of Brisbane into an established breeding colony in Brisbane. The possums were monitored weekly for the first 20 weeks of captivity, and their immune responses assessed again 12 months after capture. Over the first 5 weeks of captivity, male possums lost a mean of 8.8% of their original body weight, and females lost 15.3% over the first 6 weeks. Variation between individual possums was evident, and the 11 male possums could be divided into two groups, those that gained weight (number of animals, N = 4) and those that lost weight (N = 7) in captivity. Four males gained weight following capture, and their body weight after 20 weeks of captivity was higher than at capture. The remaining seven males lost weight over the 20 weeks following introduction into captivity, resulting in a lower weight at week 20 than at capture. All of the nine female possums lost weight and were slower to regain weight compared to the males. Plasma cortisol concentrations did not vary greatly over the 20 weeks in male possums, and the mean plasma concentration of cortisol for the 11 male possums was 7.8 ng/ml (number of samples, n = 220). The female possums showed a different pattern. The concentration of cortisol for the nine female possums at week 1 was 34.0 ng/ml, which was significantly higher than 13.3 ng/ml at week 20 (P < 0.016). No significant variation in the mean concentration of plasma thyroxine of 5.7 ng/ml occurred in the 11 male possums over the 20‐week period (n = 220). The plasma concentration of thyroxine for the nine female possums was 2.5 ng/ml (n = 54) for the first 6 weeks. At week 6, an increase in the concentration of thyroxine occurred, and a peak concentration of 6.9 ng/ml was reached at week 13. This increase correlated with the females regaining body weight. A low concentration of thyroxine is often associated with stress, thus an increase in the concentration of this hormone, combined with an increase in body weight, may indicate that these females had begun to adjust to their new environment. The seven male possums that lost weight following introduction into captivity displayed a significantly higher concentration of cortisol (9.1 compared with 5.3 ng/ml P < 0.01), and a lower concentration of thyroxine compared to the four males that gained weight following capture (4.7 compared with 7.3 ng/ml, P < 0.005). Over the 20‐week period, the total number of white blood cells increased, and the number of neutrophils increased in both males and females. The proliferative response of lymphocytes from male possums to the T‐cell mitogen, phytohaemagglutin (PHA) decreased significantly over the 20‐week period (P < 0.002). In females an initial decrease in the reactivity of lymphocytes observed over the first 10 weeks was followed by an increase in this response over the remaining 10‐week period. Twelve months ...

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Steroid Components in the Adrenal Venous Blood of Trichosurus Vulpecula (Kerr)

Cited by 27 publications

References 1 publication

Functional Zonation of Adrenocortical Tissue in the Brush Possum (Trichosurus Vulpecula)

Functional Zonation of Adrenocortical Tissue in the Brush Possum (Trichosurus Vulpecula)

Steroid production by incubated mouse adrenals

Physiological changes in brushtail possums,Trichosurus vulpecula, transferred from the wild to captivity

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