Steroid cell tumors, not otherwise specified (NOS), in an accessory ovary: a case report and literature review

Liu, Aixia; Sun, Jin Gyu; Shao, Wen-Qun; Jin, Hong-Ying; Song, Weiqing

doi:10.1016/j.ygyno.2004.12.037

Cited by 33 publications

(31 citation statements)

References 7 publications

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“…Calretinin is positive in 60-90% of tumor cells whereas inhibin reactivity ranges from 5-90%. [3] In our case tumor was strongly positive for inhibin and calretinin and weakly positive for chromagranin.…”

Section: Discussionsupporting

confidence: 47%

Steroid Cell Tumor: A Rare Ovarian Tumor

Raheja¹,

Goswami²,

Sakhija³

et al. 2018

AABS

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Ovarian steroid cell tumors are sex-cord stromal tumors that arise from lutein cells or leydig cells. These are very rare-accounting for <0.1% of all ovarian tumors.. Some of these tumors may be functional and secrete hormones. Nearly 56-77% of the cases present with hyperandrogenism. Rarely steroid cell tumors may arise in the adrenal cortex from the adrenal rest cellsWe report a case of a 60-year old lady who presented with gradual onset abdominal distension for two years. She had no other complains and had undergone hysterectomy 20 years back. Her abdomen was over distended due to a large, tense cystic, non-tender mass. Imaging studies revealed a large, mainly cystic abdominopelvic mass; however its origin could not be made out. The left adrenal gland was found to be bulky but morphologically normal. Serum DHEAS levels were normal thus ruling out adrenal pathology. Serum levels of CA 125 and CEA were also normal. Exploratory laparotomy was done. A large thin walled cyst occupied the pelvis and abdomen. . It measured 25x20x16cm and contained 4.2 litre of straw colored fluid. The fluid was drained and the entire cyst wall was excised. Ovaries were not visualized. Frozen section report of the cyst wall was suggestive of a neuroendocrine tumor. Final histopathology report was of benign steroid cell tumor not otherwise specified.

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Section: Discussionsupporting

confidence: 47%

Steroid Cell Tumor: A Rare Ovarian Tumor

Raheja¹,

Goswami²,

Sakhija³

et al. 2018

AABS

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“…The characteristic histological appearance includes the presence of diffusely arranged cells with abundant granular eosinophilic or vacuolated cytoplasm, which is often positive for fat stains, with an absence of Reinke’s crystals and stromal hyperthecosis (3,6). In addition to these microscopic features, immunohistochemistry is particularly useful for the accurate diagnosis of an SCT.…”

Section: Discussionmentioning

confidence: 99%

Ovarian steroid cell tumor, not otherwise specified: A rare case of postmenopausal vaginal bleeding

Wan

Chen

2014

Oncology Letters

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Ovarian steroid cell tumors (SCTs), not otherwise specified (NOS) are particularly rare ovarian tumors, which are composed of steroid-hormone secreting cells. The majority of patients with this tumor produce excessive quantities of testosterone and virilization is common. The current report presents a rare case of SCT in a 59-year-old female who presented with postmenopausal vaginal bleeding. The patient had experienced irregular vaginal bleeding for two months, 12 years after menopause. Transvaginal ultrasound and magnetic resonance imaging identified a solid adnexal mass and the pathological result of diagnostic curettage showed a proliferative endometrium. The patient’s serum estrogen and testosterone levels were elevated (393.71 nmol/l and 22.28 nmol/l, respectively). The patient underwent an exploratory laparotomy, hysterectomy and bisalpingectomy. The neoplasm was well-circumscribed, solid, homogeneous and yellow in color. Microscopically, the tumor was predominantly composed of granular eosinophilic or vacuolated cytoplasm. Reinke’s crystals, prominent nucleoli and Call-Exner bodies were not observed, and there was no mitotic figure. Immunohistochemistry demonstrated that the tumor cells were strongly positive for inhibin. The present rare case aims to expand the current knowledge of this type of ovarian tumor.

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“…In young women with virilization or in young adults, steroid cell tumors in other locations should be sought [10,11]. Although the tumor with virilization and rarely associated massive ascites might look malignant clinically, the tumor might prove to be benign [12].…”

Section: Discussionmentioning

confidence: 99%

An ovarian steroid cell tumor with virilization and hypothyroidism: a case report

Wang

Chen

et al. 2007

Gynecol Surg

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Steroid cell tumors are rare ovarian sex-cord stromal tumors with malignant potential. The majority of these tumors produce steroids with testosterone being the most common. The diagnosis of these rare tumors can be problematic especially in the case of a small nonpalpable ovarian tumor. A 41-year-old woman presented with the gradual onset of defeminization, mild hypothyroidism, and virilization. A physical examination revealed a relatively healthy woman with borderline hirsutism, clitoromegaly and adnexal fullness without a palpable tumor. Elevated serum levels of TSH and testosterone were found preoperatively. Five weeks after an oophorectomy, serum levels of TSH and testosterone returned to normal and menstruation returned. Nonpalpable virilizing ovarian steroid cell tumors may be difficult to diagnose. A careful study of the patient's history, the development of defeminization followed by virilization, and a "characteristic" ultrasonogram, can be helpful for diagnosis. Hormonal studies including thyroid function should also be considered in an ovarian steroid cell tumor.

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Steroid cell tumors, not otherwise specified (NOS), in an accessory ovary: a case report and literature review

Cited by 33 publications

References 7 publications

Steroid Cell Tumor: A Rare Ovarian Tumor

Steroid Cell Tumor: A Rare Ovarian Tumor

Ovarian steroid cell tumor, not otherwise specified: A rare case of postmenopausal vaginal bleeding

An ovarian steroid cell tumor with virilization and hypothyroidism: a case report

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