Steroid and nonsteroidal anti-inflammatory drugs, cognitive decline, and dementia

Ancelin, Marie-Laure; Carrière, Isabelle; Helmer, Catherine; Rouaud, Olivier; Pasquier, Florence; Berr, Claudine; Chaudieu, Isabelle; Ritchie, Karen

doi:10.1016/j.neurobiolaging.2011.09.038

Cited by 28 publications

(19 citation statements)

References 57 publications

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“…In addition, evidence has shown that corticosteroid use may lead to or accelerate hippocampal atrophy, and thus might increase dementia risk 27 28. In our study, asthmatic patients have significantly higher annual OPD visits and oral corticosteroid use than the comparisons.…”

Section: Discussionmentioning

confidence: 49%

Adult asthma increases dementia risk: a nationwide cohort study

Peng

et al. 2014

J Epidemiol Community Health

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Section: Discussionmentioning

confidence: 49%

Adult asthma increases dementia risk: a nationwide cohort study

Peng

et al. 2014

J Epidemiol Community Health

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“…Ancelin et al conducted a 7-year prospective study to investigate the effect of NSAIDs on cognitive function in elderly patients older than 65 years [ 38 ]. They found no significant association with either dementia or cognitive decline incidence.…”

Section: Nsaids and Common Geriatric Conditionsmentioning

confidence: 99%

A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly

Wongrakpanich¹,

Wongrakpanich²,

Melhado³

et al. 2018

Aging and disease

592

401

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NSAIDs, non-steroidal anti-inflammatory drugs, are one of the most commonly prescribed pain medications. It is a highly effective drug class for pain and inflammation; however, NSAIDs are known for multiple adverse effects, including gastrointestinal bleeding, cardiovascular side effects, and NSAID induced nephrotoxicity. As our society ages, it is crucial to have comprehensive knowledge of this class of medication in the elderly population. Therefore, we reviewed the pharmacodynamics and pharmacokinetics, current guidelines for NSAIDs use, adverse effect profile, and drug interaction of NSAIDs and commonly used medications in the elderly.

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“…However, a previous case study mentioned a 10‐year‐old boy who presented with dementia‐like syndrome, with memory deficit and impaired attention and executed function, caused by steroid use . A large‐scale study evaluating the effects of antiinflammatory medication on cognitive function in 7,234 community‐dwelling elderly persons found that women taking inhaled corticosteroids were at increased risk for cognitive decline over 7 years . The association of steroid use and cognitive decline could be explained by the high density of glucocorticoid receptors on the hippocampus and prefrontal cortex, which are correlated with memory and cognitive function .…”

Section: Discussionmentioning

confidence: 99%