Sternum Augmentation With Bovine Bone Substitute in the Neonate

Wattenwyl, Robert von; Siepe, Matthias; Arnold, R. E.; Beyersdorf, Friedhelm; Schlensak, Christian

doi:10.1016/j.athoracsur.2010.04.030

Cited by 4 publications

(5 citation statements)

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“…They are used in orthopedics, dental and maxillofacial surgery, as well as in periodontology and implantology, etc. [19][20][21][22][23][24]. An alternative solution, eliminating the potential complications associated with the application of materials of autogenous, allogenic or xenogenic origin, is the use of alloplastic implants for the purpose of bone replacement.…”

Section: Demineralized Freeze-dried Bone Allograft (Dfdba)mentioning

confidence: 99%

Allografts in Periodontal Regeneration

Naidu¹

2019

Madridge J Case Rep Stud

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Bone allografts are being widely used in field of periodontology, many of clinicians are unfamiliar with their preparation and processing as well as their use as safe and effective graft materials. The major issues associated with these materials are antigenicity and risk of disease transmission from donor to recipient. To minimize the risk, the production of an allograft and its distribution and implantation requires strict attention to detail through a comprehensive process. With an increasing requirement in clinical practice for bone grafting procedures, there is an increase in patient's demands for assurance that bank bone will not be infected with pathogens. To ensure the patients, surgeons should be able to cite factual information and recommendations by responsible organizations regarding safety of allografts. Knowledge of human bone allograft procurement, processing, and tracking may allow dentists to better educate patients and address concerns about this valuable treatment option. The purpose of this review is to update about the procurement, safety and efficacy of allografts.

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Section: Demineralized Freeze-dried Bone Allograft (Dfdba)mentioning

confidence: 99%

Allografts in Periodontal Regeneration

Naidu¹

2019

Madridge J Case Rep Stud

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“…The manufacturing process adheres to the strict control measures and clinical documentation in accordance with a quality assurance system based on international standards (ISO 13485 and ISO 9001). The data of safety concerning the use in humans of the bone substitute of bovine origins, were provided by the manufacturing company at registration site of the product; they are also well documented by the scientific literature available on Orthoss® (5)(6)(7)(8)(9)(10). Chemically speaking, Orthoss® is a matrix made of natural hydroxyapatite, the highly osteoconductive natural matrix possesses a topography which is very similar to the human bone.…”

Section: Introductionmentioning

confidence: 99%

“…Chemically speaking, Orthoss® is a matrix made of natural hydroxyapatite, the highly osteoconductive natural matrix possesses a topography which is very similar to the human bone. Orthoss® facilitates angiogenesis and migration of osteoblasts throughout the matrix, and when it is implanted, the matrix is structurally integrated into the surrounding bone and it is incorporated into the physiological remodeling process (8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

“…The material is available on the market as spongious granules and as blocks of variable sizes that fit the different surgeons needs. As an example, Orthoss® block is ideal for indications as bone graft substitute in high tibial osteotomy, anterior crucial ligament revision, tibial plateau fracture, bone cysts, or arthrodesis diseases (10)(11)(12)(13)(14)(15).…”

Section: Introductionmentioning

confidence: 99%

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Preparation and Characterization of an Advanced Medical Device for Bone Regeneration

et al. 2013

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Tridimensional scaffolds can promote bone regeneration as a framework supporting the migration of cells from the surrounding tissue into the damaged tissue and as delivery systems for the controlled or prolonged release of cells, genes, and growth factors. The goal of the work was to obtain an advanced medical device for bone regeneration through coating a decellularized and deproteinized bone matrix of bovine origin with a biodegradable, biocompatible polymer, to improve the cell engraftment on the bone graft. The coating protocol was studied and set up to obtain a continuous and homogeneous polylactide-co-glycolide (PLGA) coating on the deproteinized bone matrix Orthoss® block without occluding pores and decreasing the scaffold porosity. The PLGA-coated scaffolds were characterized for their morphology and porosity. The effects of PLGA polymer coating on cell viability were assessed with the 3-(4,5-dimethyl-2-thiazolyl)-2,5 diphenyl-2H-tetrazolium assay. The polymer solution concentration and the number of polymeric layers were the main variables affecting coating efficiency and porosity of the original decellularized bone matrix. The designed polymer coating protocol did not affect the trabecular structure of the original decellularized bone matrix. The PLGA-coated decellularized bone matrix maintained the structural features, and it improved the ability in stimulating fibroblasts attachment and proliferation.

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“…They are used in orthopedics, dental and maxillofacial surgery, as well as in periodontology and implantology, etc. (Baldini et al, 2011;Cao et al, 2009;Jian et al, 2008;Merkx et al, 2003;Precheur, 2007;von Wattenwyl et al, 2011). The limited possibilities of modulating the resorption time of such preparations during skeletal tissue reconstruction, however, can be related to the poorer quality of bone at the site of their application.…”

Section: Introductionmentioning

confidence: 99%