Sternal Metastasis of Breast Cancer: Ex Vivo Hypothermia and Reimplantation

Rosenberg, M; Castagno, Aldo; Nadal, Jorge; Rosales, Adolfo; Pueyrredon, Erik Pebe; Patané, Ana Karina

doi:10.1016/j.athoracsur.2010.08.029

Cited by 5 publications

(2 citation statements)

References 9 publications

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“…Pathological fractures with deformity and poor spontaneous self-healing have been reported as one of the complications associated with sternal metastasis, especially if the primary tumor was from the breast. [ 4 ]…”

Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the submandibular gland with rare metastasis to the sternum in a 52-year-old male

et al. 2016

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Adenoid cystic carcinoma (ACC) is a rare tumor, described as being one of the most biologically destructive tumors of the head and neck. It is the most common malignancy that affects the minor salivary glands. Lung and bones are the most common regions of ACC distant metastasis. To the best of our knowledge, herein, we report the first ever case of latent isolated sternal metastasis from ACC in a 52-year-old gentleman, who was diagnosed to have ACC of the submandibular gland, excised 10 years ago.

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Section: Discussionmentioning

confidence: 99%

Adenoid cystic carcinoma of the submandibular gland with rare metastasis to the sternum in a 52-year-old male

et al. 2016

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“…Interestingly, no respiratory deficiency or complications derived from insufficient or altered ventilatory mechanics were recorded and the graft integrated perfectly into the host as recently demonstrated by bone scintigraphy scans ( 60 ). As a particular modification of this technique, Rosenberg et al published the complete resection of the sternum with ex vivo curettage, cryotherapy and posterior reimplantation in a case of breast carcinoma metastasis ( 62 ).…”

Section: Reconstruction Techniquesmentioning

confidence: 99%

Sternal resection and reconstruction: a review

Aranda,

Gomez,

Fuentes

et al. 2024

J Thorac Dis

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Sternal resection and reconstruction is a rare but sometimes challenging procedure due to its profound anatomical and functional implications. For these reasons, an adequate preoperative evaluation is crucial in each patient, especially when we are faced with malignant lesions that sometimes require extensive radical resections, thus demanding an integrated reconstructive strategy that allows stabilizing the chest wall, protecting the underlying mediastinum and minimize resulting deformity. The large number of available reconstruction techniques and the lack of quality studies for their analysis mean that sternal reconstruction depends to a great extent on the consensus of experts or, more frequently, on the simple preference of each surgical team. This article aims to provide an overview of sternal resection and reconstruction. Indications for partial versus total or subtotal sternectomy are suggested and their surgical and oncological outcomes are presented. The use of rigid or semi-rigid prostheses is an ongoing debate, although recent functional data advise reserving rigid reconstructions for extensive defects. Sternectomy for primary tumors or local tumor involvement has a good prognosis with an overall survival of 5 and 10 years: 67% and 58%, respectively, provided that a radical resection with free surgical margins is performed. Breast cancer is the most common secondary sternal tumor, and surgery can offer 5-year overall survival ranging from 20% to 50% provided an R0 resection is achieved, although radical surgery does not appear to decrease rates. of recurrence. Metastases of origin other than the breast give the worst results (less than 40% at 36 months and 0% at 5 years) and although the data available on these cases are limited, the radicality of the resection does not seem to modify the survival or recurrence rates, so a conservative approach is probably more appropriate.

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Skeletal metastases from breast cancer: pathogenesis of bone tropism and treatment strategy

Fontanella

Fanotto

Rihawi

et al. 2015

Clin Exp Metastasis

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Breast cancer (BC) is the most common female cancer worldwide with approximately 10 % of new cases metastatic at diagnosis and 20-50 % of patients with early BC who will eventually develop metastatic disease. Bone is the most frequent site of colonisation and the development of skeletal metastases depends on a complex multistep process, from dissemination and survival of malignant cells into circulation to the actual homing and metastases formation inside bone. Disseminated tumor cells (DTCs) can be detected in bone marrow in approximately 30 % of BC patients, likely reflecting the presence of minimal residual disease that would eventually account for subsequent metastatic disease. Patients with bone marrow DTCs have poorer overall survival compared with patients without them. Although bone-only metastatic disease seems to have a rather indolent behavior compared to visceral disease, bone metastases can cause severe and debilitating effects, including pain, spinal cord compression, hypercalcemia and pathologic fractures. Delivering an appropriate treatment is therefore paramount and ideally it should require interdisciplinary care. Multiple options are currently available, from bisphosphonates to new drugs targeting RANK ligand and radiotherapy. In this review we describe the mechanisms underlying bone colonization and provide an update on existing systemic and locoregional treatments for bone metastases.

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Sternal Metastasis of Breast Cancer: Ex Vivo Hypothermia and Reimplantation

Cited by 5 publications

References 9 publications

Adenoid cystic carcinoma of the submandibular gland with rare metastasis to the sternum in a 52-year-old male

Adenoid cystic carcinoma of the submandibular gland with rare metastasis to the sternum in a 52-year-old male

Sternal resection and reconstruction: a review

Skeletal metastases from breast cancer: pathogenesis of bone tropism and treatment strategy

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