Sternal Marrow Changes During the First Week of Life

Haemolytic Disease of the Newborn

“…Wiener and Gordon (1948) (Faxen, 1937;Shapiro and Bassen, 1941 In one severe case reported by Mollison (1943) (Vaughan, 1946;Parsons, 1947 It is well known that the blood-sucking mite Liponyssus bacoti is a vector of Litomosoides carinii, a filarial parasite of the cotton-rat, and that the infection is used in this country and elsewhere for testing the filaricidal activity of drugs. The earlier investigations were made on wild cottonrats which were found naturally infected in the field.…”

Decreased Granulocyte-Macrophage Colony-Stimulating Factor Production by Human Neonatal Blood Mononuclear Cells and T Cells

“…A major factor contributing to this increased susceptibility to bacterial infection is the inability of the neonate to produce adequate numbers of mature neutrophils in response to such an infection (2)(3)(4). Circulating neutrophil precursors (CFU-GM) are elevated as much as 10-to 20-fold in the neonate (5), and neonatal bone marrow also contains increased numbers of neutrophil precursors (6); however, these data do not necessarily indicate an increase in the total body pool of CFU-GM. Although it has not been possible to measure the total body pool of granulocytic precursors in the human, Christensen and Rothstein (7) estimated that 20-d gestation rats, which also have increased circulating CFU-GM, contained only about 10% as many CFU-GM per g of body weight as did adult rats.…”

Review: Deficiencies in the neutrophil system of newborn infants, and the use of leukocyte transfusions in the treatment of neonatal sepsis

“…The neutrophil storage pool size, or NSPVo, was expressed as the proportion of metamyelocytes + bands + segs among 1,000 nucleated marrow cells. The marrow of sixteen of 19 septic, neutropenic neonates had a lower than normal proportion of mature neutrophils (the normal range was determined by Shapiro [47]), and those with complete depletion of the neutrophil reserves subsequently died. It was not clear whether the infection caused the neutrophil depletion or if a population of infants with Neutrophil storage pool size, assessed on bone marrow aspirate, of 19 human neonates with bacterial infection and a blood neutrophil count below the lower limit of normal for age (60).…”

“…Each dot represents the marrow NSP% from one infant. The normal range for NSPVo in newborn infants was obtained by Shapiro [47]. Values are separated into two groups (lived vs died) depending on subsequent outcome.…”