Sterilizing Efficiency of Arsphenamine, Neoarsphenamine, and Sulpharsphenamine in Experimental Syphilis

The Relation between the Trypanocidal and Spirocheticidal Activities of Neoarsphenamine: V. The Spirocheticidal Activity of the Several American Brands of Neoarsphenamine

“…Voegtlin and Dyer (7) reported that the sterilizing efficiency of the arsphenamines was identical in terms of absolute amount of arsenic used, or, in other words, "the sterilizing action of these drugs depends entirely on the amount of arsenic injected, irrespective of whether this arsenic is in the form of arsphenamine, neoarsphenamine, or sulfarsphenamine." They also observed that an essential relationship of the size of the dose to its sterilizing effect is apparent in experimental rabbit syphilis, as indicated by the definite minimum concentration of the arsenical needed to kill all of the parasites in the infected host.…”