“…After concluding that the groups do not differ on any of the GABA+ or Glx measures, we turned to examine whether neurometabolite levels are associated with sensory sensitivity or with ASD symptomatology, and whether these associations differ in direction or magnitude between the groups, as previously suggested [Brix et al, 2015;Robertson et al, 2016]. We estimated visual sensitivity by measuring thresholds for contrast detection, a task thought to rely on early visual cortex computations [Boynton, Demb, Glover, & Heeger, 1999;Ress & Heeger, 2003], and thresholds for motion discrimination, a task associated with MT+ activation [Chen, Lu, Shao, Weng, & Fang, 2017;Turkozer, Pamir, & Boyaci, 2016]. We correlated these thresholds with GABA+ and Glx measurements in the corresponding ROIs in the visual cortex (left and right MT+ for motion and occipital for contrast), however no significant correlations were observed (|r 21-38 | < 0.29, uncorrected P > 0.217).…”