Sterilization of bone allografts by microwave and gamma radiation

Singh, Rita; Singh, Deepika

doi:10.3109/09553002.2012.700166

Cited by 17 publications

(8 citation statements)

References 24 publications

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“…Besides, microwave irradiation sterilization has been considered in this study as a successful sterilization method which sterilized materials at 3 min of irradiation at 900 W and 2450 MHz. According to another study performed by Singh [26], microwave irradiation (2450 MHz and 900 W) of contaminated bone samples showed no growth of microorganisms after 2 min of exposure. Shamis et al.…”

Section: Discussionmentioning

confidence: 99%

The effect of gamma and microwave radiation sterilization on periodontological grafts for microbiological evaluation

Bargh

Silindir-Gunay

Özer

et al. 2021

APMIS

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Periodontological grafts are materials used in dentistry to regenerate lost gingival soft tissues or bone parts. In the case of direct contact with blood, the possibility of disease transmission from the source to the patient is high. This source can be an animal or a human. Therefore, the sterilization of grafts before implanting to the patient is of significant importance. The purpose of this study was to evaluate gamma radiation and microwave sterilization processes from microbiological and sterility perspectives and to compare the effectiveness of these two sterilization methods. Grafts were irradiated with 2, 4, 5, 10, 25 and 50 kGy doses of gamma radiation. Another group of same materials was irradiated by microwave for 1, 2, 3 and 4 min at 24,500 MHz and 900 W. Gamma radiation and microwave sterilization methods were evaluated as successful at minimum doses as 5 kGy and 3 min, respectively. Both gamma and microwave sterilization successfu lly sterilized periodontological grafts coded as PBG1, HBG1, HL1, PDG1, MBG3, MDG2 and PDG3. Moreover, microwave sterilization can be used as an alternative novel method to gamma radiation sterilization.

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Section: Discussionmentioning

confidence: 99%

The effect of gamma and microwave radiation sterilization on periodontological grafts for microbiological evaluation

Bargh

Silindir-Gunay

Özer

et al. 2021

APMIS

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“…Dunsmuir et al [39] have reported sterilization of femoral head allograft by microwave. The process of microwave sterilization was found to be effective for sterilization of bone allografts processed from femoral heads contaminated with Gram-positive and Gram-negative bacteria [40] . Electron beam is a high energy electron treatment which is currently used for sterilization of medical devices and in radiation therapy.…”

Section: Methods For Sterilization Of Tissue Allograftsmentioning

confidence: 99%

Radiation sterilization of tissue allografts: A review

Singh

2016

WJR

Self Cite

168

137

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Tissue substitutes are required in a number of clinical conditions for treatment of injured and diseased tissues. Tissues like bone, skin, amniotic membrane and soft tissues obtained from human donor can be used for repair or reconstruction of the injured part of the body. Allograft tissues from human donor provide an excellent alternative to autografts. However, major concern with the use of allografts is the risk of infectious disease transmission. Therefore, tissue allografts should be sterilized to make them safe for clinical use. Gamma radiation has several advantages and is the most suitable method for sterilization of biological tissues. This review summarizes the use of gamma irradiation technology as an effective method for sterilization of biological tissues and ensuring safety of tissue allografts.

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“…Studies have identified insufficient penetration as a key limitation of alternative sterilization technologies 1 . Although some evidence indicates that microwave sterilization is effective for bone allografts 28 , evidence supporting microwave sterilization in general, and its use for other tissues is limited compared to the evidence for gamma radiation.…”

Section: Impacts – Medical – United Statesmentioning

confidence: 99%

Unintended consequences of the potential phase-out of gamma irradiation

Chou¹,

Skornicki²,

Cohen³

2018

F1000Res

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The radioisotope cobalt-60 (Co-60) is important for commercial, medical, and agricultural applications. Its widespread use has meant that Co-60 can be found in less secured facilities, leading to the fear that unauthorized persons could obtain and use it to produce a “dirty bomb”. This potential security concern has led to government calls for phasing-out Co-60 and other radiation sources, despite ongoing safety and security regulations for handling, transport and use of radioactive sealed sources. This paper explores potential implications of phasing out radioisotopic technologies, including unintended safety and cost consequences for healthcare and food in the US and globally. The use of Co-60 for healthcare and agricultural applications is well-documented. Co-60 is used to sterilize single-use medical devices, tissue allografts, and a range of consumer products. Co-60 is used in Gamma Knife treatment of brain tumors in over 70,000 patients annually. Co-60 is also used to preserve food and kill insects and pathogens that cause food-borne illness. Co-60 is effective, reliable, and predictable. Limitations of alternative sterilization technologies include complex equipment, toxicities, incompatibilities with plastic, and physical hazards. Alternative ionizing radiation sources for wide-reaching applications, including e-beam and x-ray radiation, have advantages and drawbacks related to commercial scale capacity, penetrability, complexity and reliability. Identifying acceptable alternatives would require time, costs and lengthy regulatory review. FDA testing requirements and other hurdles would delay replacement of existing technologies and slow medical innovation, even delaying access to life-saving therapies. A phase-out would raise manufacturing costs, and reduce supply-chain efficiencies, potentially increasing consumer prices, and reducing supply. These consequences are poorly understood and merit additional research. Given Co-60’s importance across medical and non-medical fields, restrictions on Co-60 warrant careful consideration and evaluation before adoption.

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Sterilization of bone allografts by microwave and gamma radiation

Abstract: The study shows that sterilization of contaminated femoral head bone allografts can be achieved by short exposure of 2 min to 2450 MHz and 900 W microwave radiation.

Cited by 17 publications

References 24 publications

The effect of gamma and microwave radiation sterilization on periodontological grafts for microbiological evaluation

The effect of gamma and microwave radiation sterilization on periodontological grafts for microbiological evaluation

Radiation sterilization of tissue allografts: A review

Unintended consequences of the potential phase-out of gamma irradiation

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