tious bacteria around dental implants may lead to the formation of biofilms, [3] which can cause mucosal inflammation, which is associated with peri-implant bone loss and peri-implantitis. [4] The ongoing tissue damage and bone resorption hinder the integration of the implant into tissue. Moreover, biofilms exhibit strong antibiotic resistance and are therefore impervious to therapy. [5] Biofilm formation is a stepwise process starting from the initial bacterial adhesion, followed by microcolony formation and finally maturation into extracellular encased mature biofilms. [6] Initial bacterial adhesion is the most critical step in biofilm formation and strategies targeting the inhibition of bacterial adhesion may be of therapeutic value. [7] Recent progress in understanding the nature and complexity of biofilms has led to the development of antibiofilm strategies. Since antibiotics remain the "gold standard" therapeutics, local antibiotic delivery systems have been applied to implant surfaces to prevent initial bacterial adhesion. [8] Even though most antibiotics resist bacterial attachment simply by killing the bacteria, they increase the chance that antimicrobial resistance may develop. [9] In addition, antibiotics may kill healthy microflora and their prolonged intake will result in systemic side effects in patients. [10] Moreover, metal ions as antimicrobial agents, such as cationic compounds, semi or fully synthetic peptides, or metallic nanoparticles (silver, copper, and zinc) have been coated on implant surfaces to prevent bacterial biofilms. [11] These metallic nanoparticles triggered toxic effects at the implantation site, as well as systemic effects in other organs. [12] In the context of antifouling coatings, polymeric coatings were applied on implant materials to resist bacterial adhesion and issues of severe biofilm formation. [13] One of the critical strategies involves applying poly(ethylene glycol) (PEG) to fabricate surfaces that resist bacterial adhesion against Escherichia coli, Staphylococcus epidermidis, Streptococcus sanguinis, and Lactobacillus salivarius. [14] However, the fabrication of polymer coating involves a complicated process and the mechanism of bacterial resistance is not universal against each bacterial species. This ineffectiveness of coating could be mainly due to the complexity of the mechanisms through which bacteria attach Biomaterials may be colonized with infectious biofilms and this frequently leads to progressive loss of tissue. Bacteria encased within biofilms resist antibiotics and the host immune system. With life-threatening complications and the antibiotic resistance crisis, novel therapeutic approaches are essentially required to treat biofilm infections. Commensal microflora-particularly streptococci-modulate the immune system's ability to protect from pathogens. In imitation of this natural phenomenon, the present study describes a novel method of applying the commensal, Streptococcus oralis, as a coating on implants to prevent infectious biofilms. Implants are...