Sterility due to inhibition of sperm motility by oral administration of benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rats

Pathak, Neelam; Mishra, Pradyumna Kumar; Manivannan, B.; Lohiya, N. K.

doi:10.1016/s0944-7113(00)80051-3

Cited by 47 publications

(27 citation statements)

References 16 publications

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“…This substance is non-toxic. It has been suggested that the compound responsible for this contraceptive effect could be an alkaloid, steroid, triterpenoid, or flavonoid (Lohiya, Pathak, Mishra, & Manivannan, 2000;Lohiya et al, 2002;Pathak, Mishra, Manivannan, & Lohila, 2000).…”

Section: Papaya Composition: Nutritional Characteristics Pharmacologmentioning

confidence: 99%

Papaya: Nutritional and pharmacological characterization, and quality loss due to physiological disorders. An overview

Oliveira

Vitória

2011

Food Research International

108

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The papaya (Carica papaya L.) is a tropical fruit that is widely cultivated and consumed, both for its agreeable flavor as well as its many pharmacological properties. This review will discuss the fruit's origin and principal growing regions in the world and will briefly explore its nutritional and pharmacological attributes. In addition, we will identify and comment on some of the most common physiological disorders that occur postharvest. Such disorders compromise the quality of the fruit, bringing financial losses to the productive sector, along with serious economic and social consequences to papaya-growing countries. Among these disorders, physiological bruising, also known as "skin freckles", characterized by the appearance of blemishes on the fruit while still in its growth stage, is one of the main problems associated with the crop. Possible causes of and current information on bruising are dealt with in this article. Other physiological disorders of the papaya such as pulp flesh translucency, pulp softening, and hard lumps in papaya flesh are also discussed.

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Section: Papaya Composition: Nutritional Characteristics Pharmacologmentioning

confidence: 99%

Papaya: Nutritional and pharmacological characterization, and quality loss due to physiological disorders. An overview

Oliveira

Vitória

2011

Food Research International

108

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“…The NMR profiling of medicinal plants has found diverse applithe lipid profile in diabetic rats [21]. Papaya seeds are known to have antifungal, antibacterial and antihelminthic activity [22] and a loss of fertility was reported in several animal models fed an extract of papaya seeds [23].…”

Section: Introductionmentioning

confidence: 99%

Metabolomic profiling of the phytomedicinal constituents of Carica papaya L. leaves and seeds by 1H NMR spectroscopy and multivariate statistical analysis

Gogna

Hamid²,

Dorai

2015

Journal of Pharmaceutical and Biomedical Analysis

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“…The seed extract (50 mg/ kg body weight) when administered orally to an adult male monkey daily for 360 days, caused a significantly decreased sperm concentration starting within 30 -60 days of the treatment. The sperm from the treated animals were immotile; also, there was a decrease in sperm viability and an increased number of sperm were abnormal [32][33][34].…”

Section: B Non-hormonal Agents (Plant-derived Compounds)mentioning

confidence: 98%

Male Contraception: An Overview of the Potential Target Events

Tulsiani¹,

Abou-Haïla²

2008

EMIDDT

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The contraceptive options available to men have not changed in several decades and are still limited to the non-surgical methods of the use of a condom, a timely withdrawal, or a surgical procedure that removes a segment of the vas deferens (vasectomy). The first two approaches have relatively higher failure rates whereas the last approach is largely irreversible and may not be suitable for younger men. Thus, providing a safe, effective and readily available contraception for men has remained an unfulfilled goal. In this article, we intend to review the current status of the research and development on male contraceptives. It is apparent that the scientific community in the past few decades has witnessed impressive progress in understanding the basics of male physiology, the knowledge necessary for developing new contraceptive methods for men. We will highlight various new and improved strategies for the regulation of fertility in males. The diverse approaches that are at various stages of development and/or in clinical trials include: 1) administration of hormones, herbal extracts or chemicals to suppress/arrest sperm production in the testes (spermatogenesis); 2) interference with the delivery of spermatozoa during ejaculation by targeted blockage of vas deferens with plugs or chemicals (polymers) that prevent flow of sperm through the vas duct; 3) active or passive immunization of males with well characterized antigens/antibodies which are intended to block sperm function; and 4) administration of site-directed antagonists to block specific sperm function(s) necessary for normal fertilization. All these approaches do not involve surgery and are reversible. Our intention is to discuss the current status of various approaches which show promising results in clinical trials, particularly in China and India, the world's most populous nations.

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Sterility due to inhibition of sperm motility by oral administration of benzene chromatographic fraction of the chloroform extract of the seeds of Carica papaya in rats

Cited by 47 publications

References 16 publications

Papaya: Nutritional and pharmacological characterization, and quality loss due to physiological disorders. An overview

Papaya: Nutritional and pharmacological characterization, and quality loss due to physiological disorders. An overview

Metabolomic profiling of the phytomedicinal constituents of Carica papaya L. leaves and seeds by 1H NMR spectroscopy and multivariate statistical analysis

Male Contraception: An Overview of the Potential Target Events

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