Sterile Corneal Infiltrates Secondary to Psoriasis Exacerbations: Topical Tacrolimus as an Alternative Treatment Option

González‐Andrades, Miguel; Arias‐Santiago, Salvador; García-Serrano, J.L.; Gallardo, María del Carmen González; McAlinden, Colm

doi:10.1097/icl.0000000000000178

Cited by 5 publications

(5 citation statements)

References 18 publications

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“…The multivariate Cox regression analysis results also reveal age older than 60 and DED as risk factors for keratopathy. These findings are consistent with those of previous research[ 9 – 11 ] and demonstrate that keratopathy may develop after psoriasis.…”

Section: Discussionsupporting

confidence: 93%

“…Previous reports have revealed cases with concurrent psoriasis and keratopathy. [ 10 , 11 , 20 ] For example, Kilic et al reported on a total of 100 patients with psoriasis, 16 of whom were also diagnosed with keratopathy, including punctate epithelial erosion, vascularization, corneal opacity, and filament keratopathy. [ 10 ] The results of our study are compatible with those of Kilic et al except that our incidence rate is lower.…”

Section: Discussionmentioning

confidence: 99%

“…Third, the specific relationships between psoriasis and different types of keratopathy, such as epithelial defects or stromal opacity, were not evaluated separately, although various forms of keratopathy have been reported in patients with psoriasis. [ 10 , 11 , 20 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 9 ] Subsequently, punctuate epithelial keratitis, deep corneal opacity, sterile corneal infiltrates, and corneal melting have been observed in patients with psoriasis. [ 10 , 11 ] However, most of the previous related studies were only sporadic case reports or original study with few psoriasis cases. [ 9 – 11 ] To further substantiate the relationship between psoriasis and keratopathy, a larger case series or even nationwide cohort survey is warranted.…”

Section: Introductionmentioning

confidence: 99%

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Increased risk of keratopathy after psoriasis: A nationwide population-based study

Lee¹,

Chen²,

Lin³

et al. 2018

PLoS ONE

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BackgroundTo evaluate whether the presence of psoriasis increases the risk of keratopathy incidence by using Taiwan’s National Health Insurance Research Database (NHIRD).Methodology/Principal findingsThis retrospective cohort study used data from the NHIRD for the 2009 to 2012 period. A total of 3,648 patients diagnosed with psoriasis were enrolled in the study group while another 14,592 individuals were selected as the control group. The study group was propensity score-matched with a group of controls who had not received a diagnosis of psoriasis. Multivariate Cox regression analysis was performed to estimate the adjusted hazard ratio (aHR) of keratopathy. For the events of keratopathy, 71 patients in the study group and 208 patients in the control group developed keratopathy with a attributable risk of 23.43 per 100,000 person-months (incidence rate ratio = 1.40; P = 0.01) which correlated to the elevated cumulative probability (P = 0.03). The multivariate analysis revealed that the risk of keratopathy was higher in patients who had psoriasis (aHR = 1.31, P = 0.04). In addition, age older than 60 years (aHR = 2.10, P<0.01) and dry eye disease (aHR = 2.79, P<0.01) would also increase the risk of developing keratopathy.ConclusionsPsoriasis was associated with an increased risk of keratopathy in patients without preexisting prominent corneal disease. Moreover, the risk of incident keratopathy increases with exposure to psoriasis.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Increased risk of keratopathy after psoriasis: A nationwide population-based study

Lee¹,

Chen²,

Lin³

et al. 2018

PLoS ONE

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“…Psoriasis affects 1–3% of the adult population and is related to multiple extracutaneous manifestations [ 16 ]. Ocular involvement may occur in about 10–20% of cases, is usually bilateral and oftentimes presents in the phase of acute exacerbation [ 17 , 18 ]. Signs and symptoms may be subtle and easily missed during examination.…”

Section: Ocular Changes Associated With Parakeratosismentioning

confidence: 99%

Ocular manifestations of skin diseases with pathological keratinization abnormalities

Zdebik¹,

Zdebik²,

Fischer³

2021

pdia

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Keratinization means cytodifferentiation of keratinocytes turning into corneocytes in the stratum corneum. Disorders of keratinization (hyperkeratosis, parakeratosis and dyskeratosis) are causing many dermatological diseases, including various types of ichthyoses, pachyonychia congenita, pityriasis rubra pilaris, all subtypes of psoriasis, pityriasis lichenoides, dyskeratosis congenita, leukoplakia and keratosis follicularis, which apart from skin lesions may affect the eye's adnexae causing ectropion, entropion, blepharitis, madarosis, and trichiasis, the ocular surface causing keratitis, conjunctivitis, corneal ulceration and episcleritis, which in turn cause uveitis and various fundoscopic changes (proliferative retinopathy, retinal vasculopathy, macular oedema and birdshot chorioretinopathy). Knowledge of ocular symtoms associated with pathological keratinization is crucial, preventing sight-threatening complications such as corneal perforation, lagophthalmus, phthisis bulbi, retinal neovascularization, retinal vasculopathy and optic nerve atrophy. This review encourages dermatologists to monitor patients for ocular symptoms and encourage ophthalmologists to monitor patients for dermatological symptoms.

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Kontaktlinsenkomplikationen: Diagnostik und Therapie

Kuhn

2023

Springer Reference Medizin

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Sterile Corneal Infiltrates Secondary to Psoriasis Exacerbations: Topical Tacrolimus as an Alternative Treatment Option

Abstract: Topical tacrolimus may be considered as an alternative treatment option to corticosteroids in sterile corneal infiltrates.

Cited by 5 publications

References 18 publications

Increased risk of keratopathy after psoriasis: A nationwide population-based study

Increased risk of keratopathy after psoriasis: A nationwide population-based study

Ocular manifestations of skin diseases with pathological keratinization abnormalities

Kontaktlinsenkomplikationen: Diagnostik und Therapie

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