Sterically stabilized self-assembling reversibly cross-linked polyelectrolyte complexes with nucleic acids for environmental and medical applications

Garnett, Martin C.; Ferruti, Paolo; Ranucci, Elisabetta; Suardi, Marco; Heyde, Mieke; Sleat, Rob

doi:10.1042/bst0370713

Cited by 12 publications

(13 citation statements)

References 13 publications

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“…Monodisperse or uniform polymer particles are of great interest for a wide variety of applications, for example, in the biomedical and environmental fields and in separation sciences 1–4. The techniques used for preparing monosized and highly crosslinked polymeric microspheres have been developed in the past two decades 5–9.…”

Section: Introductionmentioning

confidence: 99%

The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization

Yau

Yao

Chan

et al. 2009

Cancer

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Objective To investigate whether patients with idiopathic recurrent acute anterior uveitis (AAU) have enthesis alterations comparable with those in patients with spondylarthritis (SpA). Methods A blinded, controlled study of enthesis evident on ultrasound (US) examination was performed in 100 patients and controls classified into 5 groups, as follows: patients with confirmed SpA (group 1), patients with recurrent AAU who were positive for HLA–B27 and did not have SpA (group 2), patients with recurrent AAU who were negative for HLA–B27 and did not have SpA (group 3), patients with forms of uveitis other than those related to SpA (group 4), and healthy controls (group 5). In total, 12 enthesis locations were explored in each patient and control subject by 2 ultrasonographers who were blinded with regard to the diagnosis. A newly developed US method, the Madrid Sonography Enthesitis Index (MASEI), in which the diagnosis of SpA is determined as a cutoff score of 18 points, was used. Results A total of 1,200 entheses were explored by US in 100 patients and controls. The MASEI cutoff limit was met or exceeded by 81%, 55.6%, 40%, 10%, and 19% of the subjects in the 5 groups, respectively. The MASEI score was significantly higher in groups 1 and 2 than in groups 4 and 5. The differences between groups 1 and 3 were also found to be significant. Conclusion Our findings indicate that a high percentage of HLA–B27–positive patients with idiopathic recurrent AAU without features of SpA have enthesis lesions comparable with those seen in patients with SpA. These data suggest that patients with recurrent AAU, especially those who are HLA–B27 positive, have an abortive or incomplete form of SpA.

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Section: Introductionmentioning

confidence: 99%

The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization

Yau

Yao

Chan

et al. 2009

Cancer

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“…Interestingly, PAA-PEG nanosized constructs crosslinked with disulfide functions, grafted with thiolend-capped DNA, were also employed as tracers of environmental organic pollutants [128].…”

Section: Paas As Dna/sirna Transfection Promotersmentioning

confidence: 99%

Polyamidoamines: Versatile Bioactive Polymers with Potential for Biotechnological Applications

Ranucci¹,

Manfredi²

2019

Chemistry Africa

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Polyamidoamines (PAAs) are multifunctional polymers prepared from prim-or sec-amines by Michael-type polyaddition with bisacrylamides. The reaction is preferably carried out at room temperature in water and without added catalysts or organic solvents. The reaction is specific. The presence in the starting monomers of additional functions, leaving apart amine, thiol and phosphine groups, does not interfere with the polymerization process. Consequently, PAAs are a polymer class endowed with unusual structural versatility. Moreover, at pH > 7 they are hydrolytically degradable in aqueous media to harmless products mostly consisting of β-amino-propionic acids. Many PAAs are remarkably biocompatible notwithstanding their polycationic nature. These properties allow to prepare multifunctional polymeric structures suitable for many diversified applications in biotechnology, such as drug carriers, transfection promoters, antiviral and antimalarial agents, hydrogels scaffolds for tissue engineering. The objective of this paper is to fully report the PAA chemistry and the studied biotechnological applications of a vast PAA library.

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“…It is finally worth mentioning that PAA‐PEG nanoparticulated constructs crosslinked with SS bonds, to which DNA end‐capped with SH group had been grafted, were also employed for a purpose widely different from transfection, that is, as environmentally safe and extremely sensitive tracers for detecting sources of water pollution …”

Section: Biomedical and Biotechnological Applications Of Paasmentioning

confidence: 99%

Poly(amidoamine)s: Past, present, and perspectives

Ferruti

2013

J. Polym. Sci. Part A: Polym. Chem.

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122

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Poly(amidoamine)s (PAAs) are a family of synthetic polymers obtained by stepwise polyaddition of prim-or sec-amines to bisacrylamides. Nearly all conceivable bisacrylamides and prim-or sec-amines can be employed as monomers endowing PAAs of a structural versatility nearly unique among stepwise polyaddition polymers. PAAs are degradable in aqueous media, including physiological fluids. Many of them are remarkably biocompatible notwithstanding their cationic character. PAAs are per se highly functional polymers and, in addition, can be further functionalized giving rise to an endless variety of polymeric structures meeting the requisites for applications in such apparently disparate fields as inorganic water pollutants scavengers, sensors, drug and protein intracellular carriers, transfection promoters, peptidomimetic antiviral and antimalarial agents. In this review, the unique chemistry of PAAs is discussed and a vast library of PAA structures and PAA applications from the beginning to the present days reported.

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Sterically stabilized self-assembling reversibly cross-linked polyelectrolyte complexes with nucleic acids for environmental and medical applications

Cited by 12 publications

References 13 publications

The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization

The outcomes of elderly patients with hepatocellular carcinoma treated with transarterial chemoembolization

Polyamidoamines: Versatile Bioactive Polymers with Potential for Biotechnological Applications

Poly(amidoamine)s: Past, present, and perspectives

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