Sterically shielded pyrrolidine nitroxides with 3-(4,5-dicarboxy-1H-1,2,3-triazol-1-yl)propyl substituent

Synthesis of 3,4-Disubstituted Pyrroline Nitroxides Containing Diphenylphosphane or Diphenylphosphane Oxide Substituents

“…Nitroxides are the most common class of stable organic radicals bearing an unpaired electron on a non-bonding molecular orbital of the N–O bond. Nitroxides are extensively utilized in diverse science and technology, including spin labels, 1 2 3 spin traps, 4 magnetic resonance imaging reagents, 5 co-oxidants, 6 dynamic nuclear polarization agents, 7 and potential therapeutic agents. 8 9 Among applications, cyclooctyne-attached nitroxide I facilitates azido-specific Cu(I)-free conjugation 10 and MITO-Carboxy Proxyl (Mito-CP) II is a potential therapeutic agent which accumulates in mitochondria 11 (Figure 1 ).…”