Steric stabilisation of self-assembled cubic lyotropic liquid crystalline nanoparticles: high throughput evaluation of triblock polyethylene oxide-polypropylene oxide-polyethylene oxide copolymers

Chong, Josephine; Mulet, Xavier; Waddington, Lynne J.; Boyd, Ben J.; Drummond, Calum J.

doi:10.1039/c1sm05181d

Cited by 187 publications

(204 citation statements)

References 38 publications

Supporting

Mentioning

193

Contrasting

Unclassified

Order By: Relevance

“…Chong et al reported the use of Pluronics ® with lower molecular weights than Pluronic ® F127 (i.e., Pluronic ® F87, F68, P123, P105, P104, P84) as steric stabilizers (Fig. 6) [160]. Pluronics ® with PEG chains greater or equal to 37 PEG units were reported to stabilize phytantriol cubosome dispersions, which had Pn3m space group symmetry.…”

Section: Amphiphilic Block Copolymersmentioning

confidence: 97%

Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

Chong

Mulet

Boyd

et al. 2015

Advances in Planar Lipid Bilayers and Liposomes

Self Cite

View full text Add to dashboard Cite

Section: Amphiphilic Block Copolymersmentioning

confidence: 97%

Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

Chong

Mulet

Boyd

et al. 2015

Advances in Planar Lipid Bilayers and Liposomes

Self Cite

View full text Add to dashboard Cite

“…To date, the most widely used surfactant for the stabilization of LCN is P407 which is composed of polyethylene oxide (PEO)-polypropylene oxide (PPO)-polyethylene oxide (PEO) block copolymer (26). The hydrophobic portion (PPO) is responsible for the anchoring to lipid bilayer, and hydrophilic portion (PEO) is oriented toward the aqueous medium.…”

Section: Discussionmentioning

confidence: 99%

“…The stabilizing effect of RH and EL might be attributed to the balance between hydrophilic and hydrophobic moieties. Hydrophilic moiety of both RH and EL is composed of PEO which acts as a steric barrier to prevent aggregation of nanoparticles, and hydrophobic moiety is composed of stearate for RH and ricinoleate for EL, respectively, which have different affinity property to bind with lipid bilayer (26). Among the concentrations of RH and EL tested, RH formed stable dispersion as low as 0.5% w/w concentration while EL failed to stabilize the dispersion at lower than 1.5% w/w concentration (Table I).…”

Section: Discussionmentioning

confidence: 99%

Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants

et al. 2013

View full text Add to dashboard Cite

Abstract. The aim of this study was to investigate the capability of two surfactants, Cremophor RH 40 (RH) and Cremophor EL (EL), to prepare liquid crystalline nanoparticles (LCN) and to study its influence on the topical delivery of finasteride (FNS). FNS-loaded LCN was formulated with the two surfactants and characterized for size distribution, morphology, entrapment efficiency, in vitro drug release, and skin permeation/retention. Influence of FNS-loaded LCN on the conformational changes on porcine skin was also studied using attenuated total reflectance Fourier-transform infrared spectroscopy. Transmission electron microscopical image confirmed the formation of LCN. The average particle size of formulations was in the range of 165.1-208.6 and 153.7-243.0 nm, respectively. The formulations prepared with higher surfactant concentrations showed faster release and significantly increased skin permeation. Specifically, LCN prepared with RH 2.5% presented higher permeation flux (0.100± 0.005 μgcm −2 h −1 ) compared with lower concentration (0.029±0.007 μgcm −2 h −1 ). Typical spectral bands of lipid matrix of porcine skin were shifted to higher wavenumber, indicating increased degree of disorder of the lipid acyl chains which might cause fluidity increase of stratum corneum. Taken together, Cremophor surfactants exhibited a promising potential to stabilize the LCN and significantly augmented the skin permeation of FNS.

show abstract

“…Organic templating techniques, using metal alkoxides, have also been used for making carriers or encapsulation systems in self-healing coatings applications [187][188][189]. The stability of the templating structures is sensitive to processing conditions and chemistry and, therefore, they are not suitable for all applications.…”

Section: Inhibitor Delivery Systemsmentioning

confidence: 99%

Self-healing coatings

Hughés¹

2015

Recent Advances in Smart Self-Healing Polymers and Composites

View full text Add to dashboard Cite

Steric stabilisation of self-assembled cubic lyotropic liquid crystalline nanoparticles: high throughput evaluation of triblock polyethylene oxide-polypropylene oxide-polyethylene oxide copolymers

Cited by 187 publications

References 38 publications

Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

Steric Stabilizers for Cubic Phase Lyotropic Liquid Crystal Nanodispersions (Cubosomes)

Enhanced Topical Delivery of Finasteride Using Glyceryl Monooleate-Based Liquid Crystalline Nanoparticles Stabilized by Cremophor Surfactants

Self-healing coatings

Contact Info

Product

Resources

About