Stereotactic volumetric resection, intracavitary carmustine wafers, and radiation therapy for brain metastases: The Moffitt Cancer Center experience.

Neuro-oncology: a selected review of ASCO 2011 abstracts

“…The results suggested improvement in all three cognitive domains (memory, executive function and fine motor) following treatment as compared with baseline. In a retrospective study of 49 patients with BM treated with surgical resection, Gliadel implantation and WBI, local control was improved compared with an institutional historical control cohort treated with surgery and WBI only [2].…”

“…, implanted at the time of brain metastases (BM) resection and one evaluating the combined use of erlotinib, a tyrosine kinase EGF receptor (EGFR) inhibitor, with whole-brain irradiation (WBI) for BM resulting from non-small-cell lung cancer [1][2][3]. A prospective single-arm Phase II trial of one to three BM treated with surgical resection, Gliadel implantation, stereotactic radiotherapy (RT) and deferred WBI evaluated neurocognitive outcome in 59 patients [1].…”