Stereotactic VA Thalamotomy for the Control of Focal Seizures:

Mori, Kazuki; Iwayama, Kaoru; Baba, H.; M, Kaminogo; Nishimura, Shinya; Ono, Kanako

doi:10.1159/000101647

Cited by 4 publications

(2 citation statements)

References 3 publications

(3 reference statements)

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“…Some studies suggested that thalamic activation seen in EEG-fMRI represent subcortical activity necessary for the maintenance of GSW discharges [33], while other studies suggested that thalamic or cingulate BOLD responses are due to spike-and-wave discharges [32,34] in patients with idiopathic generalized epilepsy. That the thalamus might have a role in seizure propagation has been supported by research using animal models with thalamic lesions [35] and a few patients with intractable partial epilepsy [36]. The EEG of patient 5 showed bilateral paroxysmal spikes, polyspikes, and slow waves, so we thought the thalamic activation may be related to widespread epileptic discharges.…”

Section: Discussionmentioning

confidence: 69%

EEG-fMRI study of the interictal epileptic activity in patients with partial epilepsy

Liu

Yang

et al. 2008

Journal of the Neurological Sciences

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Section: Discussionmentioning

confidence: 69%

EEG-fMRI study of the interictal epileptic activity in patients with partial epilepsy

Liu

Yang

et al. 2008

Journal of the Neurological Sciences

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“…We selected RF as our lesioning method as RF thalamotomies have routinely been used in the clinical practice to treat patients with tremor, pain, and to a lesser extent epilepsy [20,21] . This ablative technique not only disrupts local neuronal populations but also en passant fibers and axons from afferent and efferent fiber systems.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Anterior Thalamic Nucleus Lesions Are Not Protective against Seizures in Chronic Pilocarpine Epileptic Rats

Hamani

Ewerton

Almeida

et al. 2009

Stereotact Funct Neurosurg

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Aims: To investigate whether anterior thalamic nucleus (AN) lesions are protective against spontaneous recurrent seizures in the chronic phase of the pilocarpine model of epilepsy. Methods: Two groups of rats were treated with bilateral AN radiofrequency thalamotomies or sham surgery 2 weeks after pilocarpine-induced status epilepticus. After the lesions, animals were videotaped from the 2nd to the 8th week after status epilepticus (total 180 h). Results: During the 6 weeks of observation, no differences in the frequency of spontaneous seizures were found between animals that had bilateral AN lesions (n = 26; 3.1 ± 0.6 seizures per animal) and controls (n = 25; 3.0 ± 0.6 seizures per animal; p = 0.8). Conclusions: We conclude that AN thalamotomies were not effective in reducing the frequency of seizures during the chronic phase of the pilocarpine model of epilepsy.

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