Stereotactic radiotherapy for isolated nodal recurrence of prostate cancer

Detti, Beatrice; Bonomo, Pierluigi; Masi, Laura; Doro, R.; Cipressi, Samantha; Iermano, Carmine; Bonucci, I.; Franceschini, Davide; Brina, Lucia Di; Bakhi, M; Simontacchi, Gabriele; Meattini, Icro; Livi, Lorenzo

doi:10.1007/s00345-014-1427-x

Cited by 38 publications

(52 citation statements)

References 25 publications

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“…In this context, data on ADT‐FS were assessed. Despite only five studies having shown clear results, the data suggest SBRT could defer ADT for a median time of about 1–3 years, consistently with PFS …”

Section: Discussionmentioning

confidence: 92%

“…The exclusion reasons with references are listed in Data S2. Finally, 14 articles were selected for data extraction and subsequent qualitative synthesis.…”

Section: Resultsmentioning

confidence: 99%

“…One randomized controlled trial was found, but it did not meet all the eligibility criteria, so it was not included in the qualitative analysis . Thirteen articles were single‐arm case series/cohort studies, and one case–control series, with five (36%) prospective and nine (64%) retrospective researches . Median follow‐up period varied from 10.2 to 36.6 months (Table ).…”

Section: Resultsmentioning

confidence: 99%

“…The exclusion reasons with references are listed in Data S2. Finally, 14 articles [25][26][27][28][29][30][31][32][33][34][35][36][37][38] were selected for data extraction and subsequent qualitative synthesis. Figure 1 details the process of identification, inclusion and exclusion of studies.…”

Section: Study Selectionmentioning

confidence: 99%

“…39 Thirteen articles were single-arm case series/ cohort studies, and one case-control series, with five (36%) prospective [26][27][28]33,35 and nine (64%) retrospective researches. 25,[29][30][31][32]34,[36][37][38] Median follow-up period varied from 10.2 to 36.6 months ( Table 2).…”

Section: Study Characteristicsmentioning

confidence: 99%

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Use of stereotactic body radiation therapy for oligometastatic recurrent prostate cancer: A systematic review

et al. 2018

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The purpose of this study is to evaluate the effectiveness and safety of stereotactic body radiation therapy (SBRT) in the management of oligometastatic recurrent prostate cancer (PCa) by means of a systematic review. Six databases were searched (CENTRAL, Embase, LILACS, PubMed, Scopus and Web of Science). Additionally, hand-searching and grey literature search were performed. The main outcomes were progression-free survival (PFS) and toxicity rates. Androgen deprivation therapy-free survival (ADT-FS), local control, pattern of recurrence, cancer-specific survival and overall survival were also assessed. Risk of bias and quality of evidence were judged with the aid of specific tools. Fourteen studies were included, involving 661 patients and 899 lesions (561 nodal, 336 bone, 2 liver). Median PFS and ADT-FS were around 1 to 3 years. Local control rates varied from 82 to 100% among researches with low risk of bias. Acute and late grade 2 toxicity was observed in 2.4% and 1.1% of the patients, respectively. One case of acute and two cases of late grade 3 toxicity were registered. Only one randomized study addresses this topic. Although it does not meet all the eligibility criteria, it is useful for the discussion. A quantitative analysis was not possible, nor were subgroup analyses, due to the significant heterogeneity of the interventions and outcomes reported. Longer follow-up period is required. SBRT seems to be a safe approach to metastatic lesions that might provide disease control and defer androgen deprivation therapy (ADT). Local control is better when higher radiation doses are employed.

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Section: Discussionmentioning

confidence: 92%

“…The exclusion reasons with references are listed in Data S2. Finally, 14 articles were selected for data extraction and subsequent qualitative synthesis.…”

Section: Resultsmentioning

confidence: 99%