Stereotactic Radiosurgery of Deeply Seated Low Grade Gliomas

Barcia, Juan A.; Barcia-Salorio, J. L.; Ferrer, Cyril J.; Ferrer, Eduardo González; Algás, Rosa; Hernández, G. Ruiz

doi:10.1007/978-3-7091-9371-6_12

Cited by 39 publications

(8 citation statements)

References 12 publications

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“…The slightly reduced survival in patients with grade I astrocytomas may be due to the slightly older patients treated in this series (the mean age of patients with grade I astrocytomas in this series was 24.1 years). Barcia et al [22] published the Spanish experience with stereotactic radiosurgery for deeply seated LGA. They did not utilize a gamma knife, but rather a cobalt source and a stereoguide.…”

Section: Discussionmentioning

confidence: 99%

Gamma Knife Stereotactic Radiosurgery for Low-Grade Astrocytomas

Henderson¹,

Fakiris²,

Timmerman³

et al. 2009

Stereotact Funct Neurosurg

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Patients with low-grade astrocytoma (LGA; 8 pilocytic astrocytomas, 2 subependymal giant cell astrocytomas, 2 fibrillary astrocytomas) were selected for treatment with gamma knife stereotactic radiosurgery (GKSRS) based on having a demarcated appearance on CT or MRI and the possibility of dose sparing of adjacent eloquent structures. A median dose of 13 Gy was prescribed to the 50% isodose line, which covered the gross tumor. The median patient age was 17.4 years. The median target volume was 4.4 cm³. With a median follow-up of 48.2 months, 4-year tumor control and overall survival were 77 and 83%, respectively. Only 2 patients experienced symptomatic treatment-related toxicity. GKSRS can provide local control in cases of unresectable or recurrent LGA with a low incidence of side effects in carefully selected patients.

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Section: Discussionmentioning

confidence: 99%

Gamma Knife Stereotactic Radiosurgery for Low-Grade Astrocytomas

Henderson¹,

Fakiris²,

Timmerman³

et al. 2009

Stereotact Funct Neurosurg

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“…Stereotactic radiosurgery (SRS) has been used as an alternative treatment to radiotherapy in residual or unresectable LGGs. The experience has been limited to single-center experiences with small number of patients (Table 1) [3,[37][38][39][40][41][42][43][44][45][46][47]. It was hard to retrieve relevant absolute data about pediatric patients because in respect not only of heterogeneity of patient population but also of heterogeneity of treatment modalities that have been conducted.…”

Section: Managementmentioning

confidence: 99%

“…Tumor volume ranged between 0.2 and 180 cm 3 in the literature (7.5-180 cm 3 for SRT and 0.2-45.1 cm 3 for GKRS). Mean/median marginal doses and absolute doses for only GKRS were in the range of 11.3-15 and 2-26 Gy, respectively [3,[37][38][39][40][41][42][43][44][45][46][47].…”

Section: Managementmentioning

confidence: 99%

Gamma Knife treatment of low-grade gliomas in children

et al. 2015

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The presented literature review represents mostly single-center experiences with different patient and treatment characteristics. Accordingly, a mean/median margin dose of 11.3-15 Gy with Gamma Knife radiosurgery (GKRS) is successful in treatment of pediatric and adult low-grade glial tumor patients. However, prospective studies with a large cohort of pediatric patients should be conducted to make a more comprehensive conclusion for effectiveness and safety of GKRS in pediatric low-grade glial tumors.

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“…Beyond fractionated radiotherapy, stereotactic radiosurgery has also been raised as a possibility for treating LGGs, although no data exist to support this strategy beyond small, retrospective case series. 3,51,55,70,71 At present, there appears to be no conclusive evidence that radiotherapy is indicated LGG patients. Engel class outcomes describing the seizure profile for LGG patients following resection: Engel Class I (seizure-free) was associated with gross-total resection and lower rates of Engel classes II (rare seizures), III (meaningful seizure improvement), and IV (no improvement or worsening).…”

Section: Radiation Therapymentioning

confidence: 99%

Low-grade gliomas in adults

Sanai

Chang

Berger

2011

JNS

129

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In recent years, advances in the understanding of low-grade glioma (LGG) biology have driven new paradigms in molecular markers, diagnostic imaging, operative techniques and technologies, and adjuvant therapies. Taken together, these developments are collectively pushing the envelope toward improved quality of life and survival. In this article, the authors evaluate the recent literature to synthesize a comprehensive review of LGGs in the modern neurosurgical era.

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Stereotactic Radiosurgery of Deeply Seated Low Grade Gliomas

Cited by 39 publications

References 12 publications

Gamma Knife Stereotactic Radiosurgery for Low-Grade Astrocytomas

Gamma Knife Stereotactic Radiosurgery for Low-Grade Astrocytomas

Gamma Knife treatment of low-grade gliomas in children

Low-grade gliomas in adults

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