Stereotactic Radiosurgery of a Papillary Tumor of the Pineal Region: Case Report and Review of the Literature

Riis, Paul; Eck, Albertus T C J van; Dunker, Helmut; Bergmann, Markus; Börm, Wolfgang

doi:10.1159/000344023

Cited by 16 publications

(10 citation statements)

References 31 publications

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“…On the other hand, tumor regression after radiotherapy [10,32] or even tumor disappearance [33] was observed. Whole brain irradiation, local radiotherapy, gamma knife surgery, stereotactic linac radiosurgery were all used with different protocols [32,34,35].…”

Section: Discussionmentioning

confidence: 99%

Papillary tumor of the pineal region. Report of two cases and literature review

Koziarski

Grala

Skrobowska

2014

Neurologia i Neurochirurgia Polska

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Papillary tumor of the pineal region (PTPR) was introduced to the WHO classification in 2007. This rare tumor of little known natural history and unpredictable behavior was described in fewer than 100 cases. Its optimal treatment is not established yet. We report another two cases of PTPR in whom tumors were totally removed via supracerebellar infratentorial approach and both were treated with radiotherapy. In a 37-year-old man the operation was delayed 6 years after the first tumor diagnosis and subsequent shunt placement. He has no complaints 10 years after the onset of the disease. A 45-year-old woman has no complaints 24 months after surgery. Our experience and the data from literature indicate that a total tumor removal is the major prognostic factor.

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Section: Discussionmentioning

confidence: 99%

Papillary tumor of the pineal region. Report of two cases and literature review

Koziarski

Grala

Skrobowska

2014

Neurologia i Neurochirurgia Polska

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“…One patient was followed -up for two years. No intervention had been applied for this patient when he became symptomatic (9).…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

“…In nine reports, ten patients received SRS, which was used as an adjuvant or primary treatment (2,8,9,25,28,(30)(31)(32)(33). In four reports, the patients had no recurrence for 23, 60, 84, and 108 months, respectively (2, 9, 25, 28).…”

Section: U N C O R R E C T E D P R O O Fmentioning

confidence: 99%

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Papillary Tumor of the Pineal Region: Clinical Presentations, Prognostic Factors, Treatments, and Outcomes

Nasrollahi

Kadkhodaei

Hamedi

et al. 2016

Rep Radiother Oncol

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The pineal region is a rare site for primary tumors of the central nervous system. Papillary tumor of the pineal region (PTPR) is a relatively new phenomenon in this region. Considering the rarity of this tumor, the clinical course, treatment, and outcomes are not well studied. In the present study, we searched PubMed for relevant articles. A total of 72 articles were retrieved from PubMed. The exclusion criteria were autopsy and archive series, animal studies, and reports without clinical data. We had no access to the full -text of some articles; accordingly, 19 articles were excluded from the analysis. Data from 53 reports, including 50 case reports and three case series (a total of 73 patients), were collected and analyzed. The patients' mean age was 33.5 (± 15.4) years. Forty -two cases were male and 31 were female. The most common symptom was headache in patients (80%). Other common symptoms included visual complaints (40%), nausea (31%), memory loss (7%), Parinaud's syndrome (4%), and impaired gait (2%). Among 73 patients, 32 had undergone complete tumor resection. Twenty -nine patients had received conventional external beam radiotherapy, stereotactic radiosurgery (n, 10), brachytherapy (n, 5), and proton therapy (n, 1). Eight patients received no adjuvant therapy, and data presented in other reports were incomplete. Among the patients (n, 73), 11 received chemotherapy. Fifty patients had no evidence of recurrence at the time of report, while three patients had died. Local recurrence was the most common pattern of relapse (28%); nonetheless, parenchymal and meningeal involvement was also observed. The median disease -free survival (DFS) was 24 months, while fiveand ten -year DFS rates were 50.1% and 25.0%, respectively. The median overall survival was 24 months. Generally, PTPR has an indolent course with a tendency towards local recurrence; nonetheless, an aggressive clinical course, associated with parenchymal and meningeal metastases, is well established.

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“…Un traitement par protonthérapie a pu être proposé au patient, lui offrant alors une possibilité thérapeutique curative. Riis et al ont également rapporté un exemple de prise en charge d'une tumeur papillaire de la région pinéale par technique moderne de radiothérapie [13]. La résection chirurgicale de ces tumeurs étant associée à une assez haute morbidité, ils ont réalisé un traitement par radiochirurgie grâce à une technique de Gamma Knife, après diagnostic histologique par biopsie.…”

Section: Cancers Rares Traités Avec De Nouvelles Techniques De Radiotunclassified