2012
DOI: 10.3171/2011.9.jns101741
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Stereotactic radiosurgery for arteriovenous malformations, Part 3: outcome predictors and risks after repeat radiosurgery

Abstract: Repeat SRS for incompletely obliterated AVMs increases the eventual obliteration rate. Hemorrhage after obliteration did not occur in this series. The best results for patients with incompletely obliterated AVMs were seen in patients with a smaller residual nidus volume and no prior hemorrhages.

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Cited by 102 publications
(94 citation statements)
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“…However, obliteration rates after either SS-SRS or VS-SRS with high-grade AVMs are low (Table 7). [1][2][3]8,[10][11][12][13][14][15]17,21,22,24,25,[29][30][31][32] In a group of 47 patients with large AVMs treated with VS-SRS, "obliteration" rates were 23% for initial VS-SRS after a mean follow-up of 7.3 years; 16 patients required salvage SRS at a mean interval of 61 months, and overall rates of complete obliteration were 18%, 45%, and 56% at 5, 7, and 10 years, respectively. 12 In our experience with 69 AVM patients reviewed in a separate report, complete obliteration was observed in just 8 patients (11.6%) after VS-SRS alone, which is an unsatisfactory cure rate (unpublished data, Seymour et al, International SRS Congress, June 19, 2013).…”
Section: Avm Grading and Risk Prediction With Vs-srs Plus Surgerymentioning
confidence: 99%
“…However, obliteration rates after either SS-SRS or VS-SRS with high-grade AVMs are low (Table 7). [1][2][3]8,[10][11][12][13][14][15]17,21,22,24,25,[29][30][31][32] In a group of 47 patients with large AVMs treated with VS-SRS, "obliteration" rates were 23% for initial VS-SRS after a mean follow-up of 7.3 years; 16 patients required salvage SRS at a mean interval of 61 months, and overall rates of complete obliteration were 18%, 45%, and 56% at 5, 7, and 10 years, respectively. 12 In our experience with 69 AVM patients reviewed in a separate report, complete obliteration was observed in just 8 patients (11.6%) after VS-SRS alone, which is an unsatisfactory cure rate (unpublished data, Seymour et al, International SRS Congress, June 19, 2013).…”
Section: Avm Grading and Risk Prediction With Vs-srs Plus Surgerymentioning
confidence: 99%
“…However, decreasing volume of the residual nidus prior to salvage therapy is a reasonable goal, and increasing the volumetric response could speed the time to safe surgical salvage, as AVM size is associated with response, hemorrhage, and complications in either initial or retreatment settings. 14,20,28,37 salvage therapy and cure Assessment of cure for large AVMs is complicated, as most patients will not be cured. Obliteration is a delayed phenomenon, and outcomes may be confounded by salvage therapy, which has been reported to affect the probability of complete obliteration in nearly all reviews.…”
Section: Predictors Of Responsementioning
confidence: 99%
“…[7][8][9][10][11][12] It is characterized by high obliteration rates, especially in small lesions, and low risk of adverse effects and complications. In the present retrospective study, we were not able to demonstrate an association of the optimal K index dose with improved obliteration rates, in comparison with smaller doses.…”
Section: Discussionmentioning
confidence: 99%
“…Stereotactic radiosurgery has gained popularity in recent years. 1,2,4,5,[7][8][9][10][11][12]21 Its effect on the obliteration of AVMs is gradual, with patients remaining at risk for hemorrhage during this latency period. Complete obliteration, after a single session, has been reported to vary between 60% and 80% over 5 years.…”
mentioning
confidence: 99%