Stereotactic radiation therapy for skull base recurrences: Is a salvage approach still possible?

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“…Studies on SRS with single doses of 13.2 Gy and 14 Gy for recurrent VS reported a local control and rate >90%, with a worsening of hearing function observed in up to 42% of patients. 29 …”

Section: Srs and Fsrt: Compared Schedulesmentioning

confidence: 99%

Radiotherapy for vestibular schwannoma: Review of recent literature results

Apicella

Paolini

Deantonio

et al. 2016

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“…5 However, it was with the gradual evolution of stereotactic radiosurgery that the method of dealing with the CS pathology has really changed. A multimodal treatment strategy combining surgery with radiotherapy, as well as radiotherapy alone in selected cases, have become the main practice to handle these tumours.…”

Section: Introduction and Historical Remarksmentioning

confidence: 99%

The cavernous sinus meningiomas’ dilemma: Surgery or stereotactic radiosurgery?

Fariselli

Biroli

Signorelli

et al. 2016

Despite the advances in techniques and technologies, the management of cavernous sinus (CS) meningiomas still remains a challenge for both neurosurgeons and radiation oncologists. On the other hand, the improvement of the anatomical knowledge and the microsurgical techniques together with diffusion of radiosurgery are currently changing the treatment strategy, opening new perspectives to the patients which are suffering from such lesions. The authors reviewed here the literature data. A multidisciplinary treatment algorithm is also proposed.

“…14,105 The ability of IMRT to achieve excellent dose distribution for the most complex targets allows moderate dose escalation to the tumour while respecting dose constraints. [106][107][108] Proton radiotherapy results in an even better capability to cover the target while sparing surrounding critical structures, especially in the case of tumours with challenging "L" and "C" shapes, compared to photon IMRT and SRT. Any radiation technique needs to be combined with an optimal surgical resection aiming at tumour debulking to reduce as much of the tumour volume as possible and at achieving the best geometrical configuration to facilitate the adequate target coverage.…”

Section: Discussionmentioning

confidence: 99%

Review of photon and proton radiotherapy for skull base tumours

Fossati

Vavassori²,

Deantonio

et al. 2016

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a b s t r a c tAn extremely large variety of benign and malignant tumours occur at skull base; these tumour lesions are in the proximity to structures deputed to relevant physiologic functions, limiting extensive surgical approaches to this body district. Most recent progresses of surgery and radiotherapy have allowed to improve local control with acceptable rates of side effects. Various photon radiotherapy techniques are employed, including 3-dimensional conformal radiotherapy, intensity modulated radiotherapy (IMRT), stereotactic radiotherapy (SRT) and brachytherapy that is manly limited to the treatment of primary or recurrent nasopharyngeal carcinoma. Proton beam radiotherapy is also extensively used thanks to its physical characteristics. Our review, focusing in particular on meningioma, chordoma, and chondrosarcoma, suggests that proton therapy plays a major role in the treatment of malignant tumours whereas photon therapy still plays a relevant role in the treatment of benign tumour lesions.