Stereotactic percutaneous single dose irradiation of brain metastases with a linear accelerator

A Review of Current Radiation Therapies for the Treatment of Metastatic Brain Tumors

“…In 1987, the irst report study of 12 patients who were treated with radiosurgery using a linear accelerator for brain metastases with a dose of at least 2000 cGy was presented [33].…”

“…Many studies have been reported for SRS and RTOG recursive partitioning analysis (RPA) that was derived from studies of whole brain radiation and the use of radiation sensitizers [33]. This platform analysis has allowed a beter appreciation of results [33].…”

“…A decision platform from 'Intracranial Stereotactic Radiosurgery' shows appropriate management for patients with 1 and 2-4 brain metastasis in 2016 (Figure 1) [32,33].…”

Outcomes Following Gamma Knife for Metastases

“…For brain metastases, SRS was first evaluated for potential effectiveness as a salvage treatment for inoperable, recurrent, and/or persistent lesions. One of the earliest publications reported data from 12 patients with solitary, deep, and radioresistant brain metastases treated with LINAC in Heidelberg (Sturm, 1987). Patients received 20-30 Gy to the 80% isodose surface, and all patients had an arrest in tumor growth and a marked improvement in clinical condition beginning a few days after irradiation, with all but one of these patients being free from side effects at last follow-up.…”

Stereotactic frame for neuroradiology and -charged particle bragg peak radiosurgery of intracranial disorders

“…In Valencia, Spain Barcia-Salario and colleagues [1] have used a collimated cobalt-60 radiotherapy rotational unit. Recently, several other groups in Heidelberg [15] and Essen, West Germany, and in Boston [10], have used the photons generated by clinical linear accelerators for the stereotactic treatment of intracranial vascular disorders.…”