2014
DOI: 10.1155/2014/418270
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Stereotactic Body Radiotherapy for Metastatic and Recurrent Ewing Sarcoma and Osteosarcoma

Abstract: Background. Radiotherapy has been utilized for metastatic and recurrent osteosarcoma and Ewing sarcoma (ES), in order to provide palliation and possibly prolong overall or progression-free survival. Stereotactic body radiotherapy (SBRT) is convenient for patients and offers the possibility of increased efficacy. We report our early institutional experience using SBRT for recurrent and metastatic osteosarcoma and Ewing sarcoma. Methods. We reviewed all cases of osteosarcoma or ES treated with SBRT between 2008 … Show more

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Cited by 74 publications
(52 citation statements)
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References 12 publications
(18 reference statements)
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“…Higher total radiation doses or hypofractionation (larger daily doses) may improve local control. Stereotactic radiosurgery may allow shorter courses of treatment while still providing durable local control …”
Section: Methodsmentioning
confidence: 99%
See 1 more Smart Citation
“…Higher total radiation doses or hypofractionation (larger daily doses) may improve local control. Stereotactic radiosurgery may allow shorter courses of treatment while still providing durable local control …”
Section: Methodsmentioning
confidence: 99%
“…Patients with local recurrences also tend to fare better than those with systemic or combined recurrences, particularly if further local therapy can be administered in addition to chemotherapy. In patients with metastatic or recurrent disease with better long‐term prognoses, stereotactic body radiotherapy may offer a quicker treatment course that provides durable local control …”
Section: Methodsmentioning
confidence: 99%
“…The sole series reporting toxicity after SBRT in pediatric tumors involved 14 children and young adults with metastatic or recurrent Ewing sarcoma or osteosarcoma. [13] Two-year local control was 85%. A 17-year-old patient experienced Grade II myositis in the right iliac wing 2 months after 50 Gy in five fractions of SBRT and concurrent chemotherapy.…”
Section: Discussionmentioning
confidence: 96%
“…SBRT in pediatrics is limited given concerns for significant early toxicity and potential late effects. The sole series reporting toxicity after SBRT in pediatric tumors involved 14 children and young adults with metastatic or recurrent Ewing sarcoma or osteosarcoma . Two‐year local control was 85%.…”
Section: Discussionmentioning
confidence: 99%
“…This therapeutic modality can serve as a bridge to downstage and control disease for possible future liver transplant. However, given the unknown potential late toxicities and lack of long‐term follow‐up, the use of SBRT in pediatric patients is largely confined to clinical trials at this time, though case reports and small series have indicated promising results in a handful of children treated with SBRT to extracranial sites . Of note, stereotactic radiosurgery that uses similarly ablative doses is used routinely for benign intracranial lesions in children, such as arteriovenous malformations, as well as in the setting of recurrent malignant disease in the brain and spine, and is well tolerated …”
Section: Discussionmentioning
confidence: 99%