Stereotactic Body Radiation Therapy–Induced Abscopal Effect on Hepatocellular Carcinoma After Treatment for Lung Cancer: A Case Report

Chino, Fumiko; Pollis, Kimberly Ellen; Salama, Joseph K.; Palta, Manisha

doi:10.1002/hep.30100

Cited by 10 publications

(10 citation statements)

References 4 publications

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“…HCC is the third leading cause of cancer-related death throughout the world, resulting in approximately 700,000 deaths every year (Forner et al, 2012). Presently, radiotherapy is one of the most common method to treat HCC (Abdel-Rahman and Elsayed, 2017;Chino et al, 2018). Presently, radiotherapy is one of the most common method to treat HCC (Abdel-Rahman and Elsayed, 2017;Chino et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

“…Clinically, HCC can manifest as yellow skin, abdominal swelling due to fluid in the abdominal cavity, easy bruising from blood clotting abnormalities, loss of appetite, abdominal pain, nausea, and vomiting. Presently, radiotherapy is one of the most common method to treat HCC (Abdel-Rahman and Elsayed, 2017;Chino et al, 2018). Unfortunately, the occurrence and development of radioresistance have become a major clinical disorder in successful treatment of HCC (Wu et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Downregulation of lncRNA NEAT1_2 radiosensitizes hepatocellular carcinoma cells through regulation of miR‐101‐3p/WEE1 axis

Chen

Zhang

2018

Cell Biology International

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Radioresistance is a major obstacle in hepatocellular carcinoma (HCC) radiotherapy. Aberrant expression of long non-coding RNA (lncRNA) has been postulated to be implicated in the development of HCC radioresistance. We investigated the role of lncRNA nuclear enriched abundant transcript 1_2 (NEAT1_2) in radioresistance of HCC and its molecular mechanism in this study. We found that NEAT1_2 and WEE1 were upregulated, and miR-101-3p was downregulated in HCC tissues, as well as HCC cell lines. Downregulation of WEE1 sensitized the radiosensitivity of HCC cells, as evidenced by decreased survival fractions of Huh7 and PLC5 cells and increased percentage of apoptotic cells. Also, knockdown of NEAT1_2 exerted a reinforcing effect on the radiosensitivity of HCC cells. In addition, WEE1 was confirmed as a direct target of miR-101-3p. Upregulation of miR-101-3p obviously decreased the mRNA and protein levels of WEE1 compared with that in the miR-NC group, while transfection of anta-miR-101-3p presented the opposite effects. In parallel, NEAT1_2 was identified to interact with miR-101-3p, and NEAT1_2 upregulated the expression of WEE1 in Huh7 cells through sponging miR-101-3p. Besides, the reinforcing effect of NEAT1_2 silencing could be attenuated by downregulation of miR-101-3p. To conclude, our results support the concept that downregulation of lncRNA NEAT1_2 radiosensitizes hepatocellular carcinoma cells through regulation of miR-101-3p/WEE1 axis.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Downregulation of lncRNA NEAT1_2 radiosensitizes hepatocellular carcinoma cells through regulation of miR‐101‐3p/WEE1 axis

Chen

Zhang

2018

Cell Biology International

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“…The mechanisms leading to immune activation after SIRT remain hypothetical. In fact, several observations have suggested that some of the clinical effects of radiation therapy could be related to stimulation of the antitumor immune response, including in the rare cases where a response is induced at distant sites after radiotherapy (the so-called abscopal effect) [39][40][41]. More specifically, it has been shown that tumor irradiation may increase the release of tumor antigens and the diversity and activity of TILs [42], suggesting potential synergistic activity with immunotherapy, such as immune checkpoint inhibitors [32].…”

Section: Discussionmentioning

confidence: 99%

Retrospective analysis of the immunogenic effects of intra-arterial locoregional therapies in hepatocellular carcinoma: a rationale for combining selective internal radiation therapy (SIRT) and immunotherapy

et al. 2020

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Background: Immunotherapy represents a promising option for treatment of hepatocellular carcinoma (HCC) in cirrhotic patients but its efficacy is currently inconsistent and unpredictable. Locoregional therapies inducing immunogenic cell death, such as transarterial chemoembolization (TACE) or selective internal radiation therapy (SIRT), have the potential to act synergistically with immunotherapy. For the development of new approaches combining locoregional treatments with immunotherapy, a better understanding of the respective effects of TACE and SIRT on recruitment and activation of immune cells in HCC is needed. To address this question, we compared intra-tumor immune infiltrates in resected HCC after preoperative treatment with TACE or SIRT. Methods: Data fromr patients undergoing partial hepatectomy for HCC, without preoperative treatment (SURG, n = 32), after preoperative TACE (TACE, n = 16), or preoperative SIRT (n = 12) were analyzed. Clinicopathological factors, tumorinfiltrating lymphocytes (TILs), CD4 + and CD8 + T cells, and granzyme B (GZB) expression in resected HCC, and postoperative overall and progression-free survival were compared between the three groups. Results: Clinicopathological and surgical characteristics were similar in the three groups. A significant increase in TILs, CD4 + and CD8 + T cells, and GZB expression was observed in resected HCC in SIRT as compared to TACE and SURG groups. No difference in immune infiltrates was observed between TACE and SURG patients. Within the SIRT group, the dose of irradiation affected the type of immune infiltrate. A significantly higher ratio of CD3 + cells was observed in the peri-tumoral area in patients receiving < 100 Gy, whereas a higher ratio of intra-tumoral CD4 + cells was observed in patients receiving > 100 Gy. Postoperative outcomes were similar in all groups. Irrespective of the preoperative treatment, the type and extent of immune infiltrates did not influence postoperative survival.

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“…reported an unusual case of stereotactic body radiotherapy for primary lung cancer resulting in complete remission of primary HCC. 5 The common findings in these cases are use of hypofractionated RT without concurrent administration of systemic agents. Although these clinical observations suggest the potential role of combining RT and ICIs for metastatic HCCs,…”

Section: 7mentioning

confidence: 99%

“…3 Preclinical models established that the abscopal effect is T-cell dependent 4 and resulted from radiation "priming" of the immune system. 5 In recent years, the use of immune checkpoint inhibitors (ICIs) such as ipilimumab or pembrolizumab has greatly increased the prevalence of abscopal effects among selected patients such as those with metastatic melanoma.…”

mentioning

confidence: 99%

Exploring the mythical abscopal effect: Radiation and programmed cell death protein 1 (PD-1) blockade for hepatocellular carcinoma

Kim

Lee

2021

Clin Mol Hepatol

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Stereotactic Body Radiation Therapy–Induced Abscopal Effect on Hepatocellular Carcinoma After Treatment for Lung Cancer: A Case Report

Cited by 10 publications

References 4 publications

Downregulation of lncRNA NEAT1_2 radiosensitizes hepatocellular carcinoma cells through regulation of miR‐101‐3p/WEE1 axis

Downregulation of lncRNA NEAT1_2 radiosensitizes hepatocellular carcinoma cells through regulation of miR‐101‐3p/WEE1 axis

Retrospective analysis of the immunogenic effects of intra-arterial locoregional therapies in hepatocellular carcinoma: a rationale for combining selective internal radiation therapy (SIRT) and immunotherapy

Exploring the mythical abscopal effect: Radiation and programmed cell death protein 1 (PD-1) blockade for hepatocellular carcinoma

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