Stereotactic Body Radiation Therapy for Liver Cancer: A Review of the Technology

Kong, Vickie; Velec, Michael

doi:10.1016/j.jmir.2015.06.005

Cited by 3 publications

(1 citation statement)

References 76 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The presence of these complications affects decision-making for therapeutic options in these patients [ 2 ], and there is an unmet need for effective and less invasive therapy. There have been significant advances in the use of radiotherapy for liver tumors, and the number of patients treated with stereotactic body radiation therapy (SBRT) is increasing [ 3 , 4 , 5 , 6 ]. However, due to limited evidence reported to date, SBRT has not been described as a standard therapy in the guidelines [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of the Radiotherapy for Liver Cancer: Assessment of Local Controllability and Its Role in Multidisciplinary Therapy

Ohkoshi-Yamada

Kamimura

Shibata

et al. 2020

Cancers

View full text Add to dashboard Cite

This study investigated the efficacy and safety of radiotherapy as part of multidisciplinary therapy for advanced hepatocellular carcinoma (HCC). Clinical data of 49 HCC patients treated with radiotherapy were assessed retrospectively. The efficacy of radiotherapy was assessed by progression-free survival, disease control rate, and overall survival. Safety was assessed by symptoms and hematological assay, and changes in hepatic reserve function were determined by Child–Pugh score and albumin–bilirubin (ALBI) score. Forty patients underwent curative radiotherapy, and nine patients with portal vein tumor thrombus (PVTT) underwent palliative radiotherapy as part of multidisciplinary therapy. Local disease control for curative therapy was 80.0% and stereotactic body radiotherapy was 86.7% which was greater than that of conventional radiotherapy (60.0%). Patients with PVTT had a median observation period of 651 days and 75% three-year survival when treated with multitherapy, including radiotherapy for palliative intent, transcatheter arterial chemoembolization, and administration of molecular targeted agents. No adverse events higher than grade 3 and no changes in the Child–Pugh score and ALBI score were seen. Radiotherapy is safe and effective for HCC treatment and can be a part of multidisciplinary therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of the Radiotherapy for Liver Cancer: Assessment of Local Controllability and Its Role in Multidisciplinary Therapy

Ohkoshi-Yamada

Kamimura

Shibata

et al. 2020

Cancers

View full text Add to dashboard Cite

show abstract

Thermal management in a biological tissue in order to destroy tissue under local heating process

Barnoon

Bakhshandehfard

2021

Case Studies in Thermal Engineering

View full text Add to dashboard Cite

Assessing the Thermal Damage Induced by Radiofrequency Ablation for Localized Liver Cancer

Gupta,

Ghosh

2024

ASME Journal of Heat and Mass Transfer

View full text Add to dashboard Cite

Clinical trials are already established for high-temperature treatment of localized cancer, i.e., rise of tissue temperature to more than 550 C as an effective non-invasive method for the treatment of localized cancer. However, as the computational techniques and capacity have enhanced considerably personalized treatment planning has become a manured tool. In the present investigation, a novel treatment planning framework is being proposed for radiofrequency ablation of cancer tissue based on the tomographic image-based actual model. In patient-specific modelling, different thermal parameters like temperature history during ablation, and thermal damage profile have been virtually determined based on Penne's bioheat transfer model with appropriate boundary conditions. This advancement promises to significantly enhance the capabilities of healthcare practitioners in tailoring personalized treatment strategies for their clinical cases. By leveraging simulation outcomes, clinicians can precisely determine the most effective parameters, such as ablation power and frequency. Unfortunately, the current landscape in India presents a scarcity of specialized medical experts in the field of ablation oncology. Moreover, those who practice in this niche often rely on empirical charts rather than data-driven approaches, highlighting a critical need for increased expertise and the integration of advanced simulation technology to optimize cancer tissue ablation procedures. Last but not least optimizing different operating parameters of RF in this patient-centric approach for accurate treatment has also been discussed.

show abstract

Stereotactic Body Radiation Therapy for Liver Cancer: A Review of the Technology

Cited by 3 publications

References 76 publications

Efficacy and Safety of the Radiotherapy for Liver Cancer: Assessment of Local Controllability and Its Role in Multidisciplinary Therapy

Efficacy and Safety of the Radiotherapy for Liver Cancer: Assessment of Local Controllability and Its Role in Multidisciplinary Therapy

Thermal management in a biological tissue in order to destroy tissue under local heating process

Assessing the Thermal Damage Induced by Radiofrequency Ablation for Localized Liver Cancer

Contact Info

Product

Resources

About