Stereotactic body radiation therapy for liver metastases

Dawood, Omar Thanoon; Mahadevan, Anand; Goodman, Karyn A.

doi:10.1016/j.ejca.2009.08.011

Cited by 105 publications

(65 citation statements)

References 58 publications

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“…SBRT is a proven method for treating lung cancer, yielding excellent rates of local control for non-small-cell lung cancer and resulting in 5-year survival rates potentially comparable to that of surgery (Timmerman et al, 2010;Onishi et al, 2010). In addition, the treatment of liver metastases with SBRT has yielded promising results, achieving local control rates at 2 years of approximately 70-90% (Dawood, Mahadevan, & Goodman 2009;Rusthoven et al, 2009). …”

Section: Stereotactic Body Radiotherapy (Sbrt): a More Effective Higmentioning

confidence: 99%

STAT RAD: A Potential Real-Time Radiation Therapy Workflow

Wilson¹,

Sheng²,

Yang³

et al. 2012

Modern Practices in Radiation Therapy

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Section: Stereotactic Body Radiotherapy (Sbrt): a More Effective Higmentioning

confidence: 99%

STAT RAD: A Potential Real-Time Radiation Therapy Workflow

Wilson¹,

Sheng²,

Yang³

et al. 2012

Modern Practices in Radiation Therapy

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“…On the contrary, incorporating OAR motion in treatment planning may help to provide an improved OAR dose estimation and therefore optimized dose prescription for an SBRT treatment. More accurate clinical data may lead to better understanding of SBRT dose‐limiting toxicity15, 16, 17, 18 and normal tissue complication probabilities (NTCP),13 to improve the therapeutic ratio.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of automatic contour propagation in T2‐weighted 4DMRI for normal‐tissue motion assessment using internal organ‐at‐risk volume (IRV)

Zhang

Markova

García

et al. 2018

J Applied Clin Med Phys

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PurposeThe purpose of this study was to evaluate the quality of automatically propagated contours of organs at risk (OARs) based on respiratory‐correlated navigator‐triggered four‐dimensional magnetic resonance imaging (RC‐4DMRI) for calculation of internal organ‐at‐risk volume (IRV) to account for intra‐fractional OAR motion.Methods and MaterialsT2‐weighted RC‐4DMRI images were of 10 volunteers acquired and reconstructed using an internal navigator‐echo surrogate and concurrent external bellows under an IRB‐approved protocol. Four major OARs (lungs, heart, liver, and stomach) were delineated in the 10‐phase 4DMRI. Two manual‐contour sets were delineated by two clinical personnel and two automatic‐contour sets were propagated using free‐form deformable image registration. The OAR volume variation within the 10‐phase cycle was assessed and the IRV was calculated as the union of all OAR contours. The OAR contour similarity between the navigator‐triggered and bellows‐rebinned 4DMRI was compared. A total of 2400 contours were compared to the most probable ground truth with a 95% confidence level (S95) in similarity, sensitivity, and specificity using the simultaneous truth and performance level estimation (STAPLE) algorithm.ResultsVisual inspection of automatically propagated contours finds that approximately 5–10% require manual correction. The similarity, sensitivity, and specificity between manual and automatic contours are indistinguishable (P > 0.05). The Jaccard similarity indexes are 0.92 ± 0.02 (lungs), 0.89 ± 0.03 (heart), 0.92 ± 0.02 (liver), and 0.83 ± 0.04 (stomach). Volume variations within the breathing cycle are small for the heart (2.6 ± 1.5%), liver (1.2 ± 0.6%), and stomach (2.6 ± 0.8%), whereas the IRV is much larger than the OAR volume by: 20.3 ± 8.6% (heart), 24.0 ± 8.6% (liver), and 47.6 ± 20.2% (stomach). The Jaccard index is higher in navigator‐triggered than bellows‐rebinned 4DMRI by 4% (P < 0.05), due to the higher image quality of navigator‐based 4DMRI.ConclusionAutomatic and manual OAR contours from Navigator‐triggered 4DMRI are not statistically distinguishable. The navigator‐triggered 4DMRI image provides higher contour quality than bellows‐rebinned 4DMRI. The IRVs are 20–50% larger than OAR volumes and should be considered in dose estimation.

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“…The anatomical structures located in this region are complex, making surgical resection difficult and hazardous and controlling intraoperative bleeding to improve the outcome of hepatic hilar tumor resection is a challenge to the liver surgeon. However, radiation therapy for hepatic hilar tumor is an established palliative modality, although the optimal role of radiation therapy in the treatment of liver tumours has not been well defined (1). Historically, the liver was considered to be a relatively radiosensitive organ and it may be difficult to achieve the radiation doses required to eradicate gross tumours without causing radiation-induced liver disease (RILD), which develops ~4-8 weeks following radiation therapy (2).…”

Section: Introductionmentioning

confidence: 99%

Curative effect of stereotactic body radiotherapy on hepatic hilar carcinoma

Dang

Huang

et al. 2014

Molecular and Clinical Oncology

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Abstract. This study was conducted to investigate the effect of stereotactic body radiotherapy (SBRT) on hepatic hilar tumors. Between October, 2006 and October, 2012, we analyzed 63 unresectable hepatic hilar tumors that were treated by SBRT at the Department of Radiation Oncology, 323 Hospital of the People's Liberation Army, Xi'an, China. The patients received a total radiation dose of 45 Gy (range, 44-48 Gy) with a dose fractionation of 3-6 Gy/fx, administered for a total of 9-12 times, 2-5 times/week. At 1 and 3 months we evaluated therapeutic efficacy and 1-and 2-year survival rate. At 1 month, the patients exhibiting complete response (CR), partial response (PR), stable disease (SD) and progressive disease (PD) were 15 (23.8%), 34 (54.0%), 11 (17.5%) and 3 (4.7%), respectively. At 3 months, the number of cases with CR, PR, SD and PD was 22 (34.9%), 32 (50.8%), 3 (4.8%) and 6 (9.5%), respectively. The total effective rate, defined as CR + PR, was 85.7% (54/63). The number of patients with a tumor diameter of ≤5 cm in the CR, PR, SD and PD groups was 13 (72.2%), 4 (22.2%), 1 (5.6%) and 0 (0.0%), respectively. The number of patients with a tumor diameter of >5 cm in the CR, PR, SD and PD groups was 9 (20.0%), 28 (62.2%), 6 (13.3%) and 2 (4.5%), respectively. The 1-year survival rate of patients with a tumor diameter >5 cm was 71.4% (45/63) and the 2-year survival rate was 42.9% (27/63). In conclusion, SBRT appears to be a safe and effective treatment for hepatic hilar tumors.

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Stereotactic body radiation therapy for liver metastases

Cited by 105 publications

References 58 publications

STAT RAD: A Potential Real-Time Radiation Therapy Workflow

STAT RAD: A Potential Real-Time Radiation Therapy Workflow

Evaluation of automatic contour propagation in T2‐weighted 4DMRI for normal‐tissue motion assessment using internal organ‐at‐risk volume (IRV)

Curative effect of stereotactic body radiotherapy on hepatic hilar carcinoma

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